A Different Epidemiology of Enterovirus A and Enterovirus B Co-circulating in Korea, 2012-2019
A Different Epidemiology of Enterovirus A and Enterovirus B Co-circulating in Korea, 2012-2019
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DOI：
10.1093/jpids/piaa111
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发表时间：
2021-04-01
影响因子：
3.2
通讯作者：
Han, Myung-Guk
中科院分区：
文献类型：
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作者：
Kang, Hae Ji;Yoon, Youngsil;Han, Myung-Guk
背景肠道病毒（EV）在世界范围内频繁发生，已知与从轻度综合征到神经系统疾病的广泛临床表现相关。为了了解EV在韩国的流行病学，我们根据国家监测对2012-2019年期间EV感染病例进行了特征分析。我们收集了疑似EV感染患者的标本，并使用实时逆转录聚合酶链反应和VP 1基因测序分析数据。在收集的18261份标本中，6258例（34.3%）检出EV。虽然最常见的EV类型每年都会发生变化，但EV-A71、埃可病毒30、柯萨奇病毒B5、柯萨奇病毒A6和柯萨奇病毒A10是常见的。在人类EV中，与2种主要流行种属（EV-A和EV-B）相关的病例数在夏季达到高峰。虽然EV-A类感染1岁儿童，并与疱疹性咽峡炎和手足口病有关，但EV-B类主要与神经系统表现有关。EV-B的最高发病率是在
Background. Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012-2019 based on national surveillance.Methods. We collected specimens from patients with suspected EV infections and analyzed the data using real-time reversetranscription polymerase chain reaction and VP1 gene sequencing.Results. Among the 18 261 specimens collected, EVs were detected in 6258 (34.3%) cases. Although the most common EV types changed annually, EV-A71, echovirus 30, coxsackievirus B5, coxsackievirus A6, and coxsackievirus A10 were commonly identified. Among the human EVs, the case numbers associated with the 2 major epidemic species (EV-A and EV-B) peaked in the summer. While EV-A species affected 1-year-old children and were associated with herpangina and hand, foot, and mouth disease, EV-B species were mostly associated with neurologic manifestations. The highest incidence of EV-B species was observed in infants aged