Computation in Living Cells: Gene Assembly in Ciliates
Computation in Living Cells: Gene Assembly in Ciliates
复制标题
活细胞中的计算：纤毛虫中的基因组装
DOI：
10.1111/j.1550-7408.2004.tb00404.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Wei
中科院分区：
文献类型：
--
作者：
Andre R. O. Cavalcanti;Wei
80年代末，S在大卫·普雷斯科特的实验室中发现了杂乱的基因；从那时起，纤毛虫中的杂乱基因就一直让生物学家和计算机科学家感到困惑，因为这是一个由活细胞解决的复杂计算问题。受到错乱基因的复杂性的启发，生物学家和数学家合作写了这本跨学科的书，《活细胞中的计算：纤毛虫中的基因组装》。这本书给出了一种严格的数学和计算方法，从生物学和计算的角度研究基因破译的机制。一些争论可能延伸到总体上的重组。这本书分为四个部分。前两章包含主要针对计算机科学家的生物学背景，对生物学原理的一般概述，以及纤毛虫生物学(和混乱的基因)的介绍。这些章节足够简单，让非生物专业的学生了解纤毛虫生物学的基本概念和杂乱基因的特征，这是本书的精髓。
Scrambled genes were discovered in the late 80‘s in David Prescott's lab; since then, scrambled genes in stichotrichous ciliates have been puzzling biologists and computer scientists as a complex computational problem solved by living cells. Inspired by the complexities of scrambled genes, biologists and mathematicians have worked together to write this cross-disciplinary book,“Computation in Living Cells: Gene Assembly in Ciliates”. The book gives a rigorous mathematical and computational approach to study the mechanisms of gene unscrambling from both a biological and computational standpoint. Some of the arguments may extend to recombination in general.The book is divided in four parts. The first two chapters contain biological background targeted mostly to computer scientists, a general overview of biological principles and an introduction to ciliate biology (and scrambled genes). These chapters are simple enough for non-biology major students to understand the basic concepts of ciliate biology and characteristics of scrambled genes, which are the essence of this book.