Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats.
Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats.
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DOI：
10.1016/j.dib.2018.03.055
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发表时间：
2018-06
期刊：
影响因子：
1.2
通讯作者：
Akagi H
中科院分区：
文献类型：
--
作者：
Yamawaki Y;Nishida M;Harada K;Akagi H
早期生活中的逆境，如被忽视，会增加患重度抑郁症和焦虑症的风险。众所周知，星形胶质细胞在脑功能中起着关键作用。在本文中，我们展示了母亲分离（MS）加上社会隔离对应激反应和胶质纤维酸性蛋白（GFAP）基因表达的影响，作为星形胶质细胞的标志，在生命早期和成年期。通过强迫游泳试验评估应激反应。采用定量聚合酶链反应（qPCR）法检测GFAP基因表达水平。本文的数据提供了受早期生活压力影响的指标。
Early life adversity, such as neglect, increases the risk for major depressive disorder and anxiety disorders. It is well-known that astrocytes have key roles in brain function. In this paper, we show the effect of maternal separation (MS) coupled with social isolation on stress response and gene expression of glial fibrillary acidic protein (GFAP) as a marker of astrocytes, in early life and adulthood. Stress response was evaluated by using a forced swim test. GFAP gene expression level was evaluated by using the quantitative polymerase chain reaction (qPCR) method. The data in this article provide indexes affected by early life stress.