Atrial natriuretic factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries.
Atrial natriuretic factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries.
复制标题
心房钠尿因子抑制离体灌注大鼠肠系膜动脉中交感神经刺激引起的去甲肾上腺素释放。
DOI：
10.1016/0014-2999(86)90724-7
复制
发表时间：
1986
影响因子：
5
通讯作者：
Inagami,T
中科院分区：
文献类型：
--
作者：
Nakamaru,M;Inagami,T
在离体灌流的大鼠肠系膜动脉上，观察了心钠素(ANF)对刺激交感神经引起的去甲肾上腺素释放的影响。ANF(1 nM~0.1nM)可剂量依赖性地抑制神经刺激时[~3H]去甲肾上腺素的释放。(2)ANF(1 nM~0.1nM)对刺激神经的[~3H]去甲肾上腺素的释放有剂量依赖性抑制作用。上述结果表明，心钠素可能通过节前机制抑制大鼠肠系膜动脉去甲肾上腺素能神经传递。ANF的这种节前效应可能部分参与了它的血管扩张作用。
The effect of atrial natriuretic factor (ANF) on [3H]norepinephrine release evoked by sympathetic nerve stimulation was examined in the isolated perfused rat mesenteric arteries. ANF (1 nM to 0.1 μM) caused a dose-dependent inhibition of [3H]norepinephrine release during nerve stimulation. The present result indicates that ANF inhibits noradrenergic neurotransmission in the rat mesenteric arteries through a prejunctional mechanism. This prejunctional effect of ANF may in part contribute to its vasodilation action.