The change in blood pressure during pubertal growth
The change in blood pressure during pubertal growth
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DOI：
10.1210/jc.2004-0926
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发表时间：
2005-01-01
影响因子：
5.8
通讯作者：
Pratt, JH
中科院分区：
文献类型：
--
作者：
Shankar, RR;Eckert, GJ;Pratt, JH
儿童的血压（BP）在青春期可能增加得更多。我们选取了一组血压和体型都被密切监测的儿童，比较了青春期前3年、青春期期间（类似于青春期4.5岁）和青春期后3年的血压变化率。由于没有关于青春期的具体分期信息，我们使用青春期生长（PG）作为青春期的替代品。后者是通过连续测量高度确定的。所有受试者（n = 151）从PG前到PG后随访；没有任何关系。无论性别或种族，pg前期收缩压的年龄依赖性增加是相似的。在PG期间，男性的收缩压比PG前增加了3 - 6倍。在女性中，PG期间的收缩压升高幅度低于男性，但仍比PG前快2至4倍。男性的增加明显大于女性（P < 0.001）。pg后血压变化与pg前相似。总之，PG与收缩压显著升高有关。男性的增量明显大于女性，这与BP中众所周知的两性二态性的出现一致。
Blood pressure ( BP) in children may increase more during puberty. Using a cohort of children where BP and body size had been closely monitored, we compared the rates of change in BP during the 3-yr period before puberty, during puberty ( similar to 4.5-yr period), and the 3-yr period after puberty. Because there was no specific staging information with respect to puberty, we used pubertal growth ( PG) as a surrogate of puberty. The latter was determined from serial measurements of height. All subjects (n = 151) were followed from before the period of PG to the period after PG; none were related. An age-dependent increase in systolic BP in the pre-PG period was similar regardless of sex or race. During PG, systolic BP in males increased three to six times faster than in the pre-PG period. In females, systolic BP increased less than in males during PG but still increased two to four times faster than in the pre-PG period. The increase in males was significantly greater than in females ( P < 0.001). Post-PG changes in BP were similar to changes in pre-PG BP. In summary, PG was associated with profound increases in systolic BP. There were noticeably greater increments in males than in females consistent with the emergence of the well known sexual dimorphism in BP.