Factors associated with Staphylococcus aureus nasal carriage among healthy people in Northern China.
Factors associated with Staphylococcus aureus nasal carriage among healthy people in Northern China.
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DOI：
10.1016/j.cmi.2014.08.023
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发表时间：
2015-02
期刊：
影响因子：
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通讯作者：
X. Yan;Y. Song;X. Yu;X. Tao;J. Yan;F. Luo;H. Zhang;J. Zhang;Q. Li;L. He;S. Li;F. Meng;J. Zhang;H. Grundmann
中科院分区：
文献类型：
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作者：
X. Yan;Y. Song;X. Yu;X. Tao;J. Yan;F. Luo;H. Zhang;J. Zhang;Q. Li;L. He;S. Li;F. Meng;J. Zhang;H. Grundmann
中国地区健康携带者中金黄色葡萄球菌鼻腔携带情况及危险因素知之甚少。对北京(n=1530)和哈尔滨(n=918)2 448名健康成人(≥，年龄18岁)进行鼻部筛查。参与者接受了携带OFS的检查，并收集了2009至2011年间与健康相关的和人口统计信息。共检出403株金黄色葡萄球菌(403/2448，16.5%)，其中8株耐甲氧西林(8/2448，0.33%)。3个独立因素与金丝雀鼻腔携带有关：哈尔滨为居住城市(优势比(OR)=22.0，95%可信区间(CI)=1.41~2.85)，年龄≤为24岁(OR=91.77，95%CI=91.30~2.44)，非汉族(OR=91.58，95%CI=91.05~2.38)。根据多位点变数目串联重复序列分析(MLVA)群体遗传分析和Spat分型，MLVA复合体(MC)398和MC5a是该种质中最常见的克隆谱系。在多因素模型中，居住在哈尔滨(OR=11.77，95%CI=11.07~2.92)和有家庭成员从事医疗行业(OR=13.69，95%CI=91.14~11.92)是携带克隆系MC398的相关因素。女性(OR=3.15，95%CI=11.35~7.33)和慢性肝病史(OR=116.93，95%CI=92.91~98.59)与MC5a克隆性相关。最常见的三种痰菌型分别为t571(10.9%)、t189(9.9%)和t701(7.2%)。这些发现为中国北部健康人群中一些最成功的OFS金黄色葡萄球菌的鼻部携带和生态的决定因素提供了洞察。
There is still limited knowledge about the prevalence and risk factors of nasal carriage forStaphylococcus aureusamong healthy carriers in China. We investigated 2448 healthy adults (≥18 years of age) from Beijing (n= 1530) and Harbin (n= 918) by nasal screening. Participants were checked for carriage ofS. aureus, and health-related and demographic information between 2009 and 2011 was gathered. A total of 403S. aureus(403/2448, 16.5%) were recovered, 8 of which were methicillin resistant (8/2448, 0.33%). Three factors were independently associated withS. aureusnasal carriage: Harbin as city of residence (odds ratio (OR) = 2.0, 95% confidence interval (CI) = 1.41 to 2.85), age ≤24 years (OR = 1.77, 95% CI = 1.30–2.44) and non-Han ethnicity (OR = 1.58, 95% CI = 1.05 to 2.38). On the basis of population genetic analysis using multiple locus variable number of tandem repeats analysis (MLVA) andspatyping, MLVA complex (MC) 398 and MC5a were the most prevalent clonal lineages in this collection. In multivariate models, residing in Harbin (OR = 1.77, 95% CI = 1.07–2.92) and having household members in the healthcare profession (OR = 3.69, 95% CI = 1.14–11.92) were factors associated with carriage of clonal lineage MC398. On the other hand, female sex (OR = 3.15, 95% CI = 1.35–7.33) and a history of chronic liver disease (OR = 16.93, 95% CI = 2.91–98.59) were associated with the clonal lineage MC5a. The three most commonspatypes were t571 (10.9%), t189 (9.9%) and t701 (7.2%). These findings provide insight into the determinants of nasal carriage and ecology for some of the most successful strains ofS. aureusamong healthy people in Northern China.