Mechanical and structural changes of the rat cervix in late-stage pregnancy.
Mechanical and structural changes of the rat cervix in late-stage pregnancy.
复制标题
妊娠晚期大鼠宫颈的机械和结构变化。
DOI：
10.1016/j.jmbbm.2012.08.002
复制
发表时间：
2013
影响因子：
3.9
通讯作者：
WagonerJohnson,AmyJ
中科院分区：
文献类型：
--
作者：
Poellmann,MichaelJ;Chien,EdwardK;McFarlin,BarbaraL;WagonerJohnson,AmyJ
早产前宫颈重塑失调，是婴儿死亡和发病的主要原因。这项工作的目的是确定在妊娠后期子宫颈的机械性能的变化。测量了妊娠后15-21天（足月）大鼠宫颈的拉伸和负荷松弛特性。25%周向应变时的刚度和载荷随胎龄的增加而降低，并与子宫颈的初始周长相关。载荷松弛曲线由七参数准线性粘弹模型准确描述，其中与刚度和载荷能力相关的三个参数随着胎龄而降低，并与初始周长相关。时间依赖性参数不依赖于年龄或结构。机械性能与水含量相关，但出乎意料地与胶原蛋白含量、溶解度或组织的测量无关。颈椎刚度和结构的定量测量将导致更准确地描述颈椎重塑和预测早产。
Dysregulated remodeling of the cervix precedes preterm birth, a major cause of infant mortality and morbidity. The goal of this work was to identify changes in the mechanical properties of the cervix in late gestation. The tensile and load relaxation properties of cervices from rats 15–21 days (full term) post-conception were measured. Stiffness and load at 25% circumferential strain decreased with gestational age and correlated with the initial circumference of the cervix. Load–relaxation curves were accurately described by a seven parameter quasi-linear viscoelastic model, where three parameters associated with stiffness and load capacity decrease with gestational age and correlate with initial circumference. Time-dependent parameters did not depend on age or structure. Mechanical properties correlated with water content, but unexpectedly not with measures of collagen content, solubility, or organization. Quantitative measurements of cervical stiffness and structure will lead to a more accurate description of cervical remodeling and prediction of preterm birth.