Design framework for mechanically tunable soft biomaterial composites enhanced by modified horseshoe lattice structures
Design framework for mechanically tunable soft biomaterial composites enhanced by modified horseshoe lattice structures
复制标题
通过改进的马蹄晶格结构增强机械可调软生物材料复合材料的设计框架
作者：
Wang Dong;Xiong Yi;Zhang Biao;Zhang Yuan-Fang;Rosen David;Ge Qi
软质生物材料在许多领域有着广泛的应用。然而，一种材料只能覆盖特定范围的机械性能，例如弹性模量和拉伸性。为了提高生物软质材料的力学性能，在材料中嵌入网格结构以增强材料的力学性能。在本文中，矩形和三角形晶格结构所形成的修改马蹄形微结构，因为它们的机械性能是可调的，可以精确地定制，以匹配所需的性能，通过调整四个几何参数，长度L，半径R，宽度w和弧角θ0。提出了一种改进的马蹄形网格结构的理论设计框架，以预测几何参数对结构力学行为的影响。通过对网格结构的实验和有限元仿真验证了理论模型的正确性。结果表明，弹性模量（几kPa到几百MPa）、拉伸性（应变高达180%）和泊松比（范围从-0.5到1.2）的设计空间范围很宽。同时，对晶格-水凝胶复合材料进行了实验，验证了晶格结构对水凝胶的增强作用。本工作为预测晶格结构的力学行为和合理设计增强生物材料提供了理论依据，在组织工程、药物缓释和人工晶状体等领域具有重要的应用价值。
Soft biomaterials have a wide range of applications in many areas. However, one material can only cover a specific range of mechanical performance such as the elastic modulus and stretchability. In order to improve the mechanical performance of soft biomaterials, lattice structures are embedded to reinforce the biomaterials. In this paper, rectangular and triangular lattice structures formed by modified horseshoe microstructures are used because their mechanical properties are tunable and can be tailored precisely to match the desired properties by adjusting four geometrical parameters, the length L, radius R, width w and arc angle θ0. A theoretical design framework for the modified horseshoe lattice structures is developed to predict the dependence of the mechanical behaviors on geometrical parameters. Both experiments and finite element simulations on lattice structures are conducted to validate the theoretical models. Results show that a wide range of design space for the elastic modulus (a few kPa to hundreds of MPa), stretchability (strain up to 180%) and Poisson ratio (ranging from −0.5 to 1.2) can be achieved. Experiments on lattice–hydrogel composites are also conducted to verify the reinforcement effect of lattice structures on the hydrogel. This work provides a theoretical method to predict the mechanical behaviors of the lattice structures and aid the rational design of reinforced biomaterials, which has applications in tissue engineering, drug delivery and intraocular lenses.