Whole genome expression profiling of advance stage papillary serous ovarian cancer reveals activated pathways
Whole genome expression profiling of advance stage papillary serous ovarian cancer reveals activated pathways
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DOI：
10.1038/sj.onc.1207959
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发表时间：
2004-10-21
期刊：
影响因子：
8
通讯作者：
Birrer, MJ
中科院分区：
文献类型：
--
作者：
Donninger, H;Bonome, T;Birrer, MJ
卵巢癌是西方世界最致命的妇科癌症。病死率高的部分原因是大多数卵巢癌患者都患有基本上无法治愈的晚期疾病。为了获得晚期卵巢癌异常基因表达的全基因组评估，我们使用了包含40000多个特征的寡核苷酸微阵列来描述37例晚期乳头状浆液性原发癌。共鉴定出1191个差异显著的基因(P
Ovarian cancer is the most lethal type of gynecologic cancer in the Western world. The high case fatality rate is due in part because most ovarian cancer patients present with advanced stage disease which is essentially incurable. In order to obtain a whole genome assessment of aberrant gene expression in advanced ovarian cancer, we used oligonucleotide microarrays comprising over 40000 features to profile 37 advanced stage papillary serous primary carcinomas. We identified 1191 genes that were significantly (P