Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers
Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers
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DOI：
10.1093/ije/27.3.438
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发表时间：
1998-06-01
影响因子：
7.7
通讯作者：
Zakouji, H
中科院分区：
文献类型：
--
作者：
Tanaka, K;Tokunaga, S;Zakouji, H
咖啡对健康的潜在有害影响一直受到人们的关注，然而最近的流行病学研究表明，咖啡对酒精性肝硬化的发生和血清肝酶水平有意想不到的、可能有益的影响。特别提到与酒精消费的相互作用，在一项横断面研究，涉及12 687名健康体检者（7398名男性和5289名女性），年龄40-69岁，来自日本中部长野县的1000多个工作场所。排除有肝病史和/或血清转氨酶超过正常范围的患者。通过多变量分析控制了饮酒、体重指数、吸烟和绿色茶摄入量等可能的混杂效应。结果男性中咖啡摄入量增加与GGT活性降低强烈且独立相关（P趋势< 0.0001）：咖啡和血清GGT之间的负相关在重度饮酒者中更为明显（P < 0.0001），而在非饮酒者中不存在。然而，在女性中，咖啡仅与较低的GGT水平弱相关。血清丙氨酸氨基转移酶和丙氨酸氨基转移酶也与咖啡呈类似的负相关，咖啡和酒精摄入之间也存在相互作用。摄入绿色茶，另一种流行的来源，在日本的咖啡因，并没有实质性的影响肝酶levels.Conclusions我们的研究结果表明，咖啡可以抑制诱导的GGT在肝脏中的酒精消费，并可能保护肝细胞损伤由于酒精。
Background Attention has long been drawn to the potentially harmful effects of coffee on health, however recent epidemiological studies have suggested unexpected, possibly beneficial effects of coffee against the occurrence of alcoholic liver cirrhosis and upon serum liver enzyme levels.Methods We examined the potential inverse association between coffee drinking and serum concentrations of gamma-glutamyltransferase (GGT) and aminotransferases, with special reference to interaction with alcohol consumption, in a cross-sectional study involving 12 687 health examinees (7398 men and 5289 women) aged 40-69 pears from over 1000 workplaces in Nagano prefecture in central Japan. Those who had a history of Liver disease and/or serum aminotransferases exceeding the normal range were excluded. Possible confounding effects of alcohol consumption, body mass index, cigarette smoking, and green tea consumption were controlled through multivariate analyses.Results Increased coffee consumption was strongly and independently associated with decreased GGT activity among males (P trend < 0.0001): the inverse association between coffee and serum GGT was more evident among heavier alcohol consumers (P < 0.0001), and was absent among non-alcohol drinkers. Among females, however, coffee was only weakly related to lower GGT level. Similar inverse associations with coffee and interactions between coffee and alcohol intake were observed for serum asparate aminotransferase and alanine aminotransferase. Intake of green tea, another popular source of caffeine in Japan, did not materially influence the liver enzyme levels.Conclusions Our results suggest that coffee may inhibit the induction of GGT in the Liver by alcohol consumption, and may possibly protect against liver cell damage due to alcohol.