Involvement of the anterior thalamic radiation in boys with high functioning autism spectrum disorders: A Diffusion Tensor Imaging study
Involvement of the anterior thalamic radiation in boys with high functioning autism spectrum disorders: A Diffusion Tensor Imaging study
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DOI：
10.1016/j.brainres.2011.08.020
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发表时间：
2011-10-12
期刊：
影响因子：
2.9
通讯作者：
Schultz, Robert T.
中科院分区：
文献类型：
--
作者：
Cheon, Keun-Ah;Kim, Young-Shin;Schultz, Robert T.
背景：自闭症被假设为神经元断裂的反映。最近的一些报道暗示了自闭症的病理生理中关键的丘脑传递核和皮质-丘脑连接。因此，我们的目的是集中评估丘脑辐射的完整性，并试图利用扩散张量成像（DTI）复制韩国高功能自闭症谱系障碍（ASD）男孩先前的白质发现。方法：比较17例ASD男孩和17例正常发育对照的丘脑前辐射（ATR）、丘脑上辐射（STR）、丘脑后辐射（PTR）、胼胝体（CC）、束状神经束（UP）和下纵束神经束（ILF）的分数各向异性（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）。结果：两组在年龄、智商、利手性和头围等指标上均组内匹配。在全脑体素分析中，ASD受试者的右ATR、CC和左UP的FA显著减少，MD显著增加
Background: Autism has been hypothesized to reflect neuronal disconnection. Several recent reports implicate the key thalamic relay nuclei and cortico-thalamic connectivity in the pathophysiology of autism. Accordingly, we aimed to focus on evaluating the integrity of the thalamic radiation and sought to replicate prior white matter findings in Korean boys with high-functioning autism spectrum disorders (ASD) using Diffusion Tensor Imaging (DTI). Methods: We compared fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) in 17 boys with ASD and 17 typically developing controls in the anterior thalamic radiation (ATR), superior thalamic radiation (STR), posterior thalamic radiation (PTR), corpus callosum (CC), uncinate fasciculus (UP) and inferior longitudinal fasciculus (ILF). Results: The two groups were group-matched on age, IQ handedness and head circumference. In whole-brain voxel-wise analyses, FA was significantly reduced and MD was significantly increased in the right ATR, CC, and left UP in subjects with ASD (p