The putative hormone islet amyloid polypeptide (IAPP) induces impaired glucose tolerance in cats.
The putative hormone islet amyloid polypeptide (IAPP) induces impaired glucose tolerance in cats.
复制标题
假定的激素胰岛淀粉样多肽 (IAPP) 会导致猫的葡萄糖耐量受损。
DOI：
10.1016/0006-291x(90)92053-3
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发表时间：
1990
影响因子：
3.1
通讯作者：
Westermark,P
中科院分区：
文献类型：
--
作者：
Johnson,KH;O'Brien,TD;Jordan,K;Betsholtz,C;Westermark,P
体外研究表明，胰岛淀粉样多肽（IAPP）是骨骼肌细胞胰岛素刺激葡萄糖利用的抑制剂，也是β细胞胰岛素刺激胰岛素分泌的抑制剂。如已经表明在葡萄糖耐量受损的猫中发生的，β细胞的IAPP的表达和产生增加，因此可能实质上有助于胰岛素抵抗和胰岛素释放受损的发展，胰岛素抵抗和胰岛素释放受损是2型糖尿病的标志。然而，IAPP对活体动物葡萄糖代谢的影响此前尚未报道。在本体内研究中，我们表明合成的酰胺化IAPP在所研究的3只猫中的每一只中诱导葡萄糖耐量受损，在3只猫中的2只中具有显著的损害（葡萄糖增加至T12值的124%和234%）。胰岛素反应受损在2只葡萄糖耐受不良最严重的猫中也很明显。这些结果提供了最直接的证据，IAPP可能在2型糖尿病的发展中发挥重要作用。
Islet amyloid polypeptide (IAPP) has been implicated by in vitro studies as an inhibitor of insulin-stimulated glucose utilization by skeletal muscle cells and also as an inhibitor of insulin-stimulated insulin secretion by beta cells. Increased expression and production of IAPP by beta cells, as has been suggested to occur in cats with impaired glucose tolerance, could thus contribute substantially to the development of the insulin resistance and impaired insulin release which are the hallmarks of Type 2 diabetes mellitus. The effects of IAPP with respect to glucose metabolism in living animals, however, have not been previously reported. In the present in vivo study we show that synthetic amidated IAPP induced impaired glucose tolerance in each of the 3 cats studied, with dramatic impairment (increases in glucose to T 1 2 values of 124% and 234%) in 2 of the 3 cats. Impaired insulin responses were also evident in the 2 cats with the most dramatic states of glucose intolerance. These results provide the most direct evidence to-date that IAPP may have an important role in the development of Type 2 diabetes mellitus.