Main features of human T helper 17 cells
Main features of human T helper 17 cells
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DOI：
10.1111/nyas.12075
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发表时间：
2013-01-01
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影响因子：
--
通讯作者：
Romagnani, Sergio
中科院分区：
文献类型：
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作者：
Annunziato, Francesco;Cosmi, Lorenzo;Romagnani, Sergio
除了辅助性T细胞1型（Th 1）和Th 2细胞外，Th 17细胞是效应性CD 4（+）T细胞的第三臂。人Th 17细胞表达RORC和CD 161，来源于表达RORC的CD 161（+）前体，其迁移至淋巴组织并响应白细胞介素（IL）-1 β和IL-23分化为成熟Th 17细胞。人Th 17细胞在炎症组织中是罕见的，原因有两个：（1）Th 17细胞不产生IL-2，因此不响应TCR信号传导而增殖，这主要是因为干扰IL-2基因活化的RORC依赖性IL-4 I1介导的机制;和（2）Th 17细胞在IL-12存在下转变为Th 1表型;这种Th 17衍生的Th 1细胞被认为是非经典Th 1细胞，并且可以与经典Th 1细胞区分开。Th 17细胞在人类肿瘤中的可能作用仍不清楚，甚至存在争议。
In addition to T helper type 1 (Th1) and Th2 cells, Th17 cells are a third arm of effector CD4(+) T cells. Human Th17 cells express RORC and CD161 and originate from RORC-expressing CD161(+) precursors, which migrate to lymphoid tissue and differentiate into mature Th17 cells in response to interleukin (IL)-1 beta and IL-23. Human Th17 cells are rare in inflammed tissues for two reasons: (1) Th17 cells do not produce IL-2 and, therefore, do not proliferate in response to TCR signaling, mainly because of RORC-dependent IL-4I1-mediated mechanisms that interfere with IL-2 gene activation; and (2) Th17 cell shift to a Th1 phenotype in the presence of IL-12; such Th17-derived Th1 cells are considered to be nonclassical Th1 cells and can be distinguished from classical Th1 cells. The possible role of Th17 cells in human tumors is still unclear and even controversial.