Long-Term Outcomes of Intra-Arterial Chemotherapy for Progressive or Unresectable Pilocytic Astrocytomas: Case Studies.
Long-Term Outcomes of Intra-Arterial Chemotherapy for Progressive or Unresectable Pilocytic Astrocytomas: Case Studies.
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进行性或不可切除的毛细胞星形细胞瘤的动脉内化疗的长期结果：案例研究。
DOI：
10.1093/neuros/nyaa588
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发表时间：
2021
期刊：
影响因子：
4.8
通讯作者：
Neuwelt,EdwardA
中科院分区：
文献类型：
--
作者：
Uluc,Kutluay;Siler,DominicA;Lopez,Ricardo;Varallyay,Csanad;Netto,JoaoProla;Firkins,Jenny;Lacy,Cindy;Huddleston,Amy;Ambady,Prakash;Neuwelt,EdwardA
背景与典型的毛细胞星形细胞瘤相比，进行性和/或不可切除的毛细胞星形细胞瘤（PA）预后较差。早期放疗（RT）可能会对该患者人群产生严重的长期神经认知副作用。动脉内（IA）化疗是静脉内（IV）化疗的一种可行的替代或补充，这可能有利于避免早期RT。目的
BACKGROUNDProgressive and/or unresectable pilocytic astrocytomas (PAs) carry a poor prognosis compared to typical PA. Early radiotherapy (RT) may have severe long-term neurocognitive side effects in this patient population. Intra-arterial (IA) chemotherapy is a viable alternative or addition to intravenous (IV) chemotherapy, which may be beneficial in avoidance of early RT.OBJECTIVE