PRESENCE OF BOTH ODOR IDENTIFICATION AND DETECTION DEFICITS IN ALZHEIMERS-DISEASE
PRESENCE OF BOTH ODOR IDENTIFICATION AND DETECTION DEFICITS IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0361-9230(87)90129-8
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发表时间：
1987-05-01
影响因子：
3.8
通讯作者：
GREGOR, T
中科院分区：
文献类型：
--
作者：
DOTY, RL;REYES, PF;GREGOR, T
最近对阿尔茨海默氏病患者的研究表明：（a）与嗅觉功能相关的大脑区域（包括嗅球和内嗅皮层）的结构和生化变化显著;（B）识别气味的能力下降。根据这些发现，我们对相对大量的根据严格标准诊断为轻度至中度阿尔茨海默病的患者进行了宾夕法尼亚大学气味识别测试（UPSIT）和强制选择苯乙醇气味检测阈值测试。与年龄、性别和种族匹配的正常对照组相比，这些个体在两种类型的嗅觉测试中表现出一致且显著的下降（ps < 0.001）。令人惊讶的是，很少有患者意识到他们的疾病，尽管它在疾病过程的早期出现。这些研究结果表明，气味识别和气味检测问题都存在于阿尔茨海默氏症型痴呆症中，并提高了识别和气味检测问题存在于阿尔茨海默氏症型痴呆症中的可能性，并提高了气味识别问题可能继发于气味检测问题的可能性。
Recent studies of Alzheimer''s disease patients have demonstrated (a) marked structural and biochemical alterations in brain regions associated with olfactory function (including the olfactory bulb and entorhinal cortex) and (b) decrements in the ability to identify odorants. In light of such findings, we administered the University of Pennsylvania Smell Identification Test (UPSIT) and a forced-choice phenyl ethyl alcohol odor detection threshold test to a relatively large number of patients diagnosed, on the basis of stringent criteria, as having mild to moderately severe Alzheimer''s disease. Compared to age-, gender-, and race-matched normal controls, these individuals evidenced consistent and marked decrements on both types of olfactory tests (ps < 0.001). Surprisingly few of the patients were aware of their disorder, despite its appearance early in the disease process. These findings indicate that both odor identification and odor detection problems are present in dementia of the Alzheimer''s type, and raise the possibility that the identification and odor detection problems are present in dementia of the Alzheimer''s type, and raise the possibility that the odor identification problem may be secondary to the odor detection problem.