Mediterranean-inspired diet lowers the ratio of serum phospholipid n-6 to n-3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects
Mediterranean-inspired diet lowers the ratio of serum phospholipid n-6 to n-3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects
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DOI：
10.1093/ajcn.83.3.575
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发表时间：
2006-03-01
影响因子：
7.1
通讯作者：
Friberg, P
中科院分区：
文献类型：
--
作者：
Ambring, A;Johansson, M;Friberg, P
背景：在坚持地中海饮食（MID）的人群中，心血管疾病的死亡率和发病率降低。虽然这种关联的潜在机制知之甚少，但增加n-3系列多不饱和脂肪酸的饮食量的重要性已被强调。目的：我们研究了向健康受试者提供MID是否会影响1）炎症过程和内皮指数，如血管调节和血管内皮生长因子（VEGF）和2）血清磷脂脂肪酸组成。设计：共有22名受试者（10名女性）以交叉方式接受MID或普通瑞典饮食（OSD）4周。分析脂多糖刺激前后的脂质和脂肪酸、高敏C反应蛋白和白细胞介素6的浓度;白细胞和血小板的数量;以及VEGF和单核细胞趋化蛋白1。结果：MID后n-6与n-3脂肪酸的血浆比率显著低于OSD后（（x）在条形SEM上：4.72 ± 0.19和2.60 ± 0.17。P < 0.0001）。与OSD相比，MID后C反应蛋白和白细胞介素6浓度均无显著变化。白细胞总数和血小板总数在MID后比OSD后分别降低10%（P < 0.05）和15%（P < 0.001）。血清VEGF浓度低于MID后比OSD后（237 - 30和206 +/- 25 pg/mL，分别为P = 0.0014）。结论：MID减少血小板和白细胞的数量和VEGF浓度在健康受试者。这可能与较高的n-3脂肪酸血清浓度有关，这促进了磷脂的有利组成。
Background: Reduced cardiovascular mortality and morbidity have been shown in persons adhering to Mediterranean-inspired diets (MIDs). Although the underlying mechanisms of this association are poorly understood, the importance of increasing dietary amounts of polyunsaturated fatty acids of the n-3 series has been emphasized.Objective: We investigated whether a MID provided to healthy subjects would affect 1) the inflammatory process and endothelial indexes such as vasoregulation and vascular endothelial growth factor (VEGF) and 2) serum phospholipid fatty acid composition.Design: A total of 22 subjects (10 women) received a MID or an ordinary Swedish diet (OSD) for 4 wk in a crossover fashion. Concentrations of lipids and fatty acids, high-sensitivity C-reactive protein, and interleukin 6, both before and after lipopolysaccharide stimulation; the number of leukocytes and platelets; and VEGF and monocyte chemoattractant protein 1 were analyzed.Results: The plasma ratio of n-6 to n-3 fatty acids was substantially lower after the MID than after the OSD ((x) over bar SEM: 4.72 +/- 0.19 and 2.60 +/- 0.17. respectively; P < 0.0001). Neither C-reactive protein nor interleukin 6 concentrations changed significantly after the MID compared with the OSD. The total number of leukocytes and platelets was 10% (P < 0.05) and 15% (P < 0.001) lower, respectively, after the MID than after the OSD. Serum VEGF concentrations were lower after the MID than after the OSD (237 30 and 206 +/- 25 pg/mL, respectively; P = 0.0014).Conclusions: A MID reduces the number of platelets and leukocytes and VEGF concentrations in healthy subjects. This may be linked to higher serum concentrations of n-3 fatty acids, which promote a favorable composition of phospholipids.