PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer?
PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer?
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DOI：
10.1016/j.ejphar.2020.173226
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发表时间：
2020-08-15
影响因子：
5
通讯作者：
Najafi, Masoud
中科院分区：
文献类型：
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作者：
Ashrafizadeh, Milad;Zarrabi, Ali;Najafi, Masoud
膀胱癌是世界范围内发病率和死亡率较高的疾病，预计未来几年其发病率还会更高。许多因素涉及膀胱癌的发展，如生活方式和药物。然而，遗传因素似乎在膀胱癌的发展和进展中起着重要作用。磷酸酶和张力蛋白同源物（Phosphatase and tensin homolog，PTEN）是一种肿瘤相关转录因子，通过负靶向PI 3 K/Akt/mTOR信号通路与肿瘤细胞增殖和侵袭能力降低相关。在本综述中，我们的目的是探讨PTEN在膀胱癌细胞中的作用以及上游调节剂如何影响PTEN在这种危及生命的疾病中的作用。PTEN的下调与癌细胞的不良预后、化学抗性和进展相关。此外，microRNA、长链非编码RNA、环状RNA和其他分子途径如NF-kB能够靶向膀胱癌细胞中的PTEN。值得注意的是，抗肿瘤药物如山奈酚、β-榄香烯和索拉非尼上调PTEN的表达以发挥其对膀胱癌细胞的抑制作用。
Bladder cancer accounts for high morbidity and mortality around the world and its incidence rate is suggested to be higher in following years. A number of factors involve in bladder cancer development such as lifestyle and drugs. However, it appears that genetic factors play a significant role in bladder cancer development and progression. Phosphatase and tensin homolog (PTEN) is a cancer-related transcription factor that is corelated with reduced proliferation and invasion of cancer cells by negatively targeting PI3K/Akt/mTOR signaling pathway. In the present review, we aimed to explore the role of PTEN in bladder cancer cells and how upstream modulators affect PTEN in this life-threatening disorder. Down-regulation of PTEN is associated with poor prognosis, chemoresistance and progression of cancer cells. Besides, microRNAs, long non-coding RNAs, circular RNAs and other molecular pathways such as NF-kB are able to target PTEN in bladder cancer cells. Notably, anti-tumor drugs such as kaempferol, beta-elemene and sorafenib upregulate the expression of PTEN to exert their inhibitory effects on bladder cancer cells.