Comparison of virulence between clinical and environmental isolates of Aspergillus fumigatus
Comparison of virulence between clinical and environmental isolates of Aspergillus fumigatus
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DOI：
10.1007/s100960050184
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发表时间：
1998-11-01
影响因子：
4.5
通讯作者：
Holden, DW
中科院分区：
文献类型：
--
作者：
Aufauvre-Brown, A;Brown, JS;Holden, DW
采用小鼠侵袭性肺曲霉病混合感染模型，比较了3株临床分离株和4株环境分离株经鼻腔接种后的毒力。利用紫外线诱变技术从临床菌株中筛选出有色分生孢子突变株，并与亲本菌株和环境菌株进行了比较。当考虑到与孢子颜色突变相关的毒力轻微降低时，一些环境菌株的毒力低于其相应的临床菌株。这些差异是否可以解释许多侵袭性肺曲霉病患者似乎感染了单一的烟曲霉菌株的观察结果，还有待确定。
Using a mixed infection model of murine invasive pulmonary aspergillosis, the comparative virulence of three clinical and four environmental isolates of Aspergillus fumigatus was investigated after intranasal inoculation. Coloured conidiospore mutants were first derived from clinical strains by ultraviolet mutagenesis and then compared with the parental strains and environmental strains. When the slight reductions in virulence associated with the spore colour mutations were taken into account, some environmental strains were shown to be less virulent than their corresponding clinical strains. It has yet to be determined whether these differences can account for the observation that many patients with invasive pulmonary aspergillosis appear to be infected with a single strain of Aspergillus fumigatus.