SERUM ESTROGEN-LEVELS IN POSTMENOPAUSAL WOMEN - COMPARISON OF AMERICAN WHITES AND JAPANESE IN JAPAN
SERUM ESTROGEN-LEVELS IN POSTMENOPAUSAL WOMEN - COMPARISON OF AMERICAN WHITES AND JAPANESE IN JAPAN
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DOI：
10.1038/bjc.1990.316
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发表时间：
1990-09-01
影响因子：
8.8
通讯作者：
HENDERSON, BE
中科院分区：
文献类型：
--
作者：
SHIMIZU, H;ROSS, RK;HENDERSON, BE
对日本绝经后妇女(91例)和美国绝经后白人妇女(38例)血清雌二醇(E_1)、雌二醇(E_2)和性激素结合球蛋白(SHBG)水平进行了测定。这些日本妇女被故意选为来自农村农业区，以便获得尽可能接近日本传统生活方式的样本，而这种生活方式导致了日本乳腺癌的低发病率。在美国女性中，E_1水平为47%，E_2水平为36%，更大；在根据日本人较低的体重进行调整后，这些差异仅减少到43%和27%。这些结果在统计学上都具有非常重要的意义。日本女性和美国女性的SHBG水平几乎没有差异。这些关于E1和E2的结果可能是解释为什么日本和美国的乳腺癌发病率在绝经后继续存在进一步差异的重要部分。
Serum oestron (E1), oestradiol (E2) and sex hormone binding globulin (SHBG) levels were studied in postmenopausal Japanese women in Japan (n = 91) and postmenopausal American white women (n = 38). The Japanese women were deliberately chosen to be from a rural agricultural area in order to get samples which represent as closely as possible the tradiational Japanese ''lifestyle'' that gave rise to the low rates of breast cancer in Japan. E1 levels were 47%, and E2 levels 36%, greater in the American women; these differences were only reduced to 43% and 27% after adjustment for the lower weight of the Japanese. These results were all statistically highly significant. There was little difference in SHBG levels between the Japanese and the American women. These results for E1 and E2 could be an important part of the explantation why Japanese and American breast cancer rates continue to diverge further after the menopause.