Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube
Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube
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DOI：
10.1080/14786410701192827
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发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Lin, Qing-Sheng
中科院分区：
文献类型：
--
作者：
Jiang, Jian-Guo;Huang, Xiao-Juan;Lin, Qing-Sheng
酸枣仁（Ziziphus jujube，SZJ）为枣科植物酸枣（Ziziphus sporba Mill.）变种刺人参是一种治疗失眠的中药。为了分析其有效成分，我们对黄酮类、皂苷类和多糖类三种化合物的镇静催眠作用进行了研究和比较。从SZJ中提取黄酮、皂苷和多糖，并在动物试验前以17 g/kg/d的剂量分别经口给予小鼠一定天数。采用小鼠自主运动和协调运动实验观察3种化合物对小鼠行为学的影响，采用巴比妥钠诱导小鼠睡眠时间实验分析3种化合物对小鼠睡眠的影响。结果表明，黄酮类化合物和皂苷类化合物能显著减少小鼠的步行时间和协调运动能力，在阈下剂量（40 mg·kg ~（-1）ip）下能显著延长小鼠的睡眠时间，在阈上剂量（50 mg·kg ~（-1）ip）下能显著增加小鼠的睡眠次数。多糖在所有动物试验中均未显示出任何显著性。结果表明，皂苷类化合物的镇静催眠作用强于黄酮类化合物，多糖类化合物的镇静催眠作用不明显。
Semen Ziziphus jujube (SZJ), the seeds of Ziziphus jujuba Mill. var. spinosa, is a kind of traditional Chinese medicine used for its action on insomnia. In order to analyze the effective component, we investigated and compared the sedative and hypnotic effects of three kinds of compounds, flavonoids, saponins, and polysaccharides. Flavonoids, saponins, and polysaccharides were extracted from SZJ and orally administered to mice separately at 17 g kg(-1) per day for certain days before animal tests. Spontaneous motility and coordinated movement tests were used to observe the effects of the three kinds of compounds on the mouse behavior, and sodium barbital-induced sleeping time of mouse were tested to analyze the effects of the three kinds of compounds on the sleep of mouse. Results show that flavonoids and saponins caused a significant reduction of walking time and coordinated movement ability of mouse, significantly prolonged its sleeping time at 40 mg kg(-1), ip, subthreshold dose and increased the sleeping number of animals at 50 mg kg(-1), ip, superthreshold dose induced by coeliac injection of sodium barbital. Polysaccharides did not show any significance in all animal tests. Comparative analysis showed that saponins had a more effective sedative and hypnotic function than that of flavonoids, polysaccharides did not show a sedative and hypnotic effect.