Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.
Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.
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DOI：
10.4049/jimmunol.1502139
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发表时间：
2016-03-01
期刊：
影响因子：
--
通讯作者：
Rosenblum MD
中科院分区：
文献类型：
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作者：
Nosbaum A;Prevel N;Truong HA;Mehta P;Ettinger M;Scharschmidt TC;Ali NH;Pauli ML;Abbas AK;Rosenblum MD
表达foxp3的调节性T细胞（Tregs）存在于组织中，它们控制炎症并介导组织特异性功能。老鼠和人类的皮肤含有大量treg；然而，这些细胞如何在皮肤中起作用的机制在很大程度上仍然未知。在这里，我们发现Tregs促进皮肤伤口愈合。高度激活的treg在皮肤损伤后早期积累，这些细胞的特异性消融导致伤口再上皮化和伤口愈合的动力学延迟。损伤皮肤中的Tregs可减弱IFNγ的产生和促炎巨噬细胞的积累。受伤后，Tregs诱导表皮生长因子受体（EGFR）的表达。Treg中EGFR的谱系特异性缺失导致Treg在损伤皮肤中的积累和激活减少，伤口愈合延迟，促炎巨噬细胞积累增加。综上所述，我们的研究结果揭示了treg在促进皮肤伤口修复中的新作用，并表明treg利用EGFR途径介导这些作用。
Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control inflammation and mediate tissue-specific functions. The skin of mice and humans contain a large number of Tregs; however, the mechanisms of how these cells function in skin remain largely unknown. Here, we show that Tregs facilitate cutaneous wound healing. Highly activated Tregs accumulated in skin early after wounding and specific ablation of these cells resulted in delayed wound re-epithelialization and kinetics of wound closure. Tregs in wounded skin attenuated IFNγ production and pro-inflammatory macrophage accumulation. Upon wounding, Tregs induce expression of the epidermal growth factor receptor (EGFR). Lineage-specific deletion of EGFR in Tregs resulted in reduced Treg accumulation and activation in wounded skin, delayed wound closure and increased pro-inflammatory macrophage accumulation. Taken together, our results reveal a novel role for Tregs in facilitating skin wound repair and suggest that Tregs utilize the EGFR pathway to mediate these effects.