Analysis of human leukocyte antigen (HLA)-G polymorphism in normal women and in women with recurrent spontaneous abortions
Analysis of human leukocyte antigen (HLA)-G polymorphism in normal women and in women with recurrent spontaneous abortions
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DOI：
10.1111/j.1365-2370.2004.00487.x
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发表时间：
2004-12-01
期刊：
影响因子：
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通讯作者：
Agrawal, S
中科院分区：
文献类型：
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作者：
Abbas, A;Tripathi, P;Agrawal, S
人白细胞抗原(HLA)-G是一种非经典I类抗原。它表达有限，但在母体界面处表达量高。这种独特的HLA-G表达模式表明，它可能对怀孕期间胎儿的存活很重要。在本研究中，120例复发性自然流产（RSA）妇女和120例生育对照妇女进行了HLA-G位点的基因分型。这是第一个描述印度正常生育和RSA妇女HLA-G多态性的报告。复发性胎儿丢失妇女的等位基因HLA-G*010103较高。有趣的是，HLA-G*010105和G*010108等位基因在正常生育女性中完全不存在，而在RSA女性中分别存在，频率分别为1.7%和0.4%。G*010107等位基因在两组中均不存在。G*0105N零等位基因在我国人群中的频率为13.8%，高于世界其他人群。我们的数据支持HLA-G多态性可能导致复发性胎儿丢失的假设。
Human leukocyte antigen (HLA)-G is a non-classical class I antigen. It has limited expression, but is high at the foetomaternal interface. This unique expression pattern of HLA-G suggests that it might be important for survival of the foetus during pregnancy. In the present study, 120 women with recurrent spontaneous abortions (RSA) and 120 fertile control women were genotyped for the HLA-G locus. This is the first report describing HLA-G polymorphism in normal fertile and RSA women from India. The allele HLA-G*010103 was higher in women with recurrent foetal losses. Interestingly, the HLA-G*010105 and G*010108 alleles were totally absent in normal fertile women but present in RSA women with frequencies of 1.7% and 0.4%, respectively. Allele G*010107 was absent in both the groups. The frequency of the null allele G*0105N was high (13.8%) in our population as compared to other world populations. Our data support the hypothesis that HLA-G polymorphism may contribute to recurrent foetal loss.