Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives
Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives
复制标题
DOI：
10.1039/c2ob06641f
复制
发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Sekine, Mitsuo
中科院分区：
文献类型：
--
作者：
Ohkubo, Akihiro;Nishino, Yudai;Sekine, Mitsuo
本文报道了含有5-甲基-2-硫代胞苷（m（5）s（2）C）残基的DNA和2 '-OMe-RNA探针，利用2-硫代羰基的堆积效应和空间位阻效应，可以选择性地与相应的含肌苷的RNA靶分子强结合。
In this paper, we report DNA and 2'-OMe-RNA probes containing 5-methyl-2-thiocytidine (m(5)s(2)C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group.