Effects of conjugated equine estrogen with and without three different progestogens on lipoproteins, high-density lipoprotein subfractions, and apolipoprotein A-I.
Effects of conjugated equine estrogen with and without three different progestogens on lipoproteins, high-density lipoprotein subfractions, and apolipoprotein A-I.
复制标题
结合马雌激素加或不加三种不同孕激素对脂蛋白、高密度脂蛋白亚组分和载脂蛋白 A-I 的影响。
DOI：
10.1097/00006250-199102000-00014
复制
发表时间：
1991
影响因子：
7.2
通讯作者：
Stillman,RJ
中科院分区：
文献类型：
--
作者：
Miller,VT;Muesing,RA;LaRosa,JC;Stoy,DB;Phillips,EA;Stillman,RJ
The effects of conjugated equine estrogen and subsequent cyclical progestogen supplementation on lipoprotein and apolipoprotein AI levels were investigated in three groups of postmenopausal women. Unopposed conjugated equine estrogen (0.625 mg) lowered total cholesterol 4-8% and low-density lipoprotein (LDL) cholesterol 12-19% below pre-treatment levels in all three groups. Levels of highdensity lipoprotein (HDL) cholesterol and apolipoprotein AI were increased 9-13 and 9-18%, respectively, with unopposed estrogen. The increase in HDL cholesterol was mainly due to increases in the high-density lipoprotein 2 (HDL 2) subfraction. Addition of medroxyprogesterone acetate, norethindrone acetate, or d, l-norgestrel at doses shown previously to provide protection against endometrial hyperplasia reversed some of the beneficial estrogen effects, reducing levels of HDL cholesterol 14-17%, HDL 2 cholesterol 22-37%, and apolipoprotein AI 11-15% from those obtained cholesterol 22-37%, and apolipoprotein AI 11-15% from those obtained with unopposed estrogen. The LDL cholesterol levels fell 12-19% with unopposed estrogen but remained 7-12% below baseline when progestogens were added. These observations demonstrate that after 3 months of treatment, all three progestogens reversed some of the favorable effects of unopposed estrogen on lipoproteins but permitted a continued modest reduction in LDL cholesterol.
