Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall
Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall
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DOI：
10.1046/j.1525-1594.1998.06137.x
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发表时间：
1998-05-01
影响因子：
2.4
通讯作者：
Takano, H
中科院分区：
文献类型：
--
作者：
Nishimura, T;Tatsumi, E;Takano, H
我们研究了长时间非搏动左心搭桥术（LHB）中由于全身脉压降低而引起的主动脉形态学变化。将19只成年山羊分为3组，非搏动组进行非搏动LHB，脉动组进行搏动LHB，对照组为正常对照组。平均主动脉脉压分别为12、47和37毫米汞柱。对降主动脉进行形态学检查。无搏动组肌壁明显变薄，平滑肌细胞体积比明显降低。在SMC类型分类上，低活性、低收缩性的SMCs比例较高，细胞密度较其他组增加。这些结果表明，长时间无搏动性LHB引起主动脉形态萎缩。
We investigated the morphological changes in the aorta due to reduced systemic pulse pressure in prolonged nonpulsatile left heart bypass (LHB). Nineteen adult goats were divided into 3 groups, the nonpulsatile group in which nonpulsatile LHB was conducted, the pulsatile group in which pulsatile LHB was conducted, and the control group used as the normal control. The average aortic pulse pressures were 12, 47, and 37 mm Hg, respectively. The descending aorta was subjected to morphological examination. In the nonpulsatile group, the wall was significantly thinner, and the volume ratio of smooth muscle cells (SMCs) was much lower. In terms of the SMC type classification, the proportion of SMCs with low activity and low contractility was higher, and the cell density of the SMCs was increased compared to those in the other groups. These results indicate that prolonged nonpulsatile LHB causes morphological atrophic changes in the aorta.