Global variation in gene expression and the value of diverse sampling.
Global variation in gene expression and the value of diverse sampling.
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DOI：
10.1016/j.coisb.2016.12.018
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发表时间：
2017-02
影响因子：
3.7
通讯作者：
Tishkoff SA
中科院分区：
文献类型：
--
作者：
Kelly DE;Hansen MEB;Tishkoff SA
基因组学时代加速了我们对遗传和表观遗传因素如何影响人类正常可变性状和疾病风险的理解。然而，大多数“组学”研究都集中在生活在城市中心的个体，主要来自欧洲和亚洲，忽视了世界各地人群中存在的遗传和环境变异。不同种族人群中基因调控的比较研究为我们了解进化力量如何塑造复杂性状背后的遗传和分子机制提供了信息，研究不同环境背景下的基因表达有助于解剖疾病相关途径，如免疫反应。这些方法对于公平应用基因组学和医学至关重要。
The genomics era has accelerated our understanding of how genetic and epigenetic factors influence both normal variable traits and disease risk in humans. However, the majority of “omics” studies have focused on individuals living in urban centers, primarily from Europe and Asia, neglecting much of the genetic and environmental variation that exists across worldwide populations. Comparative studies of gene regulation in ethnically diverse populations are informing our understanding of how evolutionary forces have shaped the genetic and molecular mechanisms underlying complex traits, and studying gene expression in different environmental contexts is enabling the dissection of disease-related pathways such as immune response. Such approaches are vital to the equitable application of genomics and medicine.