Association between functional genetic variants in retinoid X receptor-α/γ and the risk of gestational diabetes mellitus in a southern Chinese population.
Association between functional genetic variants in retinoid X receptor-α/γ and the risk of gestational diabetes mellitus in a southern Chinese population.
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中国南方人群中视黄醇X受体-α/γ功能性遗传变异与妊娠期糖尿病风险之间的关联
DOI：
10.1042/bsr20211338
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发表时间：
2021-10-29
影响因子：
4
通讯作者：
Liu DB
中科院分区：
文献类型：
--
作者：
Yu XY;Song LP;Zheng HT;Wei SD;Wen XL;Huang B;Liu DB
为探讨视黄醇X受体-α/γ(RxR-α/γ)基因功能性遗传变异(RxR-αrs4842194 G>；A、RxR-γrs100537 A>；G和rs2134095 T>；C)对广西中国地区5 73例妊娠期糖尿病患者和74 0例糖耐量正常孕妇进行病例对照研究。使用优势比(OR)及其相应的95%可信区间(CI)来评估遗传变异与妊娠期糖尿病之间关联的强度。调整年龄和体重指数后，Logistic回归分析显示rs2134095与妊娠期糖尿病的风险显著相关(CC与TT/TC：调整后OR=0.71，95%CI=0.56~0.90)，经Bonferroni多项检验校正后，这一结果仍具有高度统计学意义(P=0.004)。分层分析显示，rs2134095与年龄<30岁(调整后OR=0.61，95%CI=0.39~0.97)、体重指数>22 kg/m2(调整后OR=0.46，95%CI=0.30~0.70)、收缩压>120 mm Hg(调整后OR=1.96，95%CI=1.14~3.36)、糖化血红蛋白A1c(HbA1c)、糖化血红蛋白(HbA1c)、糖化血红蛋白6.5%(调整后OR=1.41，95%CI=1.11~1.78)、TG≤1.7mmo1/L(调整后OR=2.57，95%CI=1.45~4.53)、TC≤5.18mmo1/L(调整后OR=1.58，95%CI=1.13~2.22)、高密度脂蛋白胆固醇≤1.5mmo1/L(调整后OR=1.70，95%CI=1.16~2.49)和低密度脂蛋白胆固醇(LDL-c)及GT；隐性遗传模型下，3.12 mmol/L(调整OR=1.47，95%CI=1.08~2.00)受试者。我们还发现rs2134095与年龄(P交互作用=0.039)、体重指数前期(P交互作用=0.040)和甘油三酯(P交互作用=0.025)交互作用，影响个体对妊娠期糖尿病的遗传易感性。Rs2134095T>；C通过单基因座和/或复杂的基因-基因和基因-环境联合作用与妊娠期糖尿病的风险显著相关。需要更大的样本量和不同的人群研究来证实这一发现。
To clarify the effect of retinoid X receptor-α/γ (RXR-α/γ) genes functional genetic variants (RXR-α rs4842194 G>A, RXR-γ rs100537 A>G and rs2134095 T>C) on the risk of gestational diabetes mellitus (GDM), a case–control study with 573 GDM patients and 740 pregnant women with normal glucose tolerance was performed in Guangxi area of China. An odds ratio (OR) with its corresponding 95% confidence interval (CI) was used to assess the strengths of the association between genetic variation and GDM. After adjustment of age and pre-BMI, the logistic regression analysis showed that the rs2134095 was significantly associated with GDM risk (CC vs. TT/TC: adjusted OR = 0.71, 95% CI = 0.56–0.90) in all subjects, and this result remained highly significant after Bonferroni’s correction for multiple testing (P=0.004). The stratified analysis showed that rs2134095 was significantly associated with the risk of GDM among age > 30 years (adjusted OR = 0.61, 95% CI = 0.39–0.97), BMI > 22 kg/m2 (adjusted OR = 0.46, 95% CI = 0.30–0.70), systolic blood pressure (SBP) > 120 mmHg (adjusted OR = 1.96, 95% CI = 1.14–3.36), glycosylated hemoglobin A1c (HbA1c) < 6.5% (adjusted OR = 1.41, 95% CI = 1.11–1.78), TG ≤ 1.7 mmol/l (adjusted OR = 2.57, 95% CI = 1.45–4.53), TC ≤ 5.18 mmol/l (adjusted OR = 1.58, 95% CI = 1.13–2.22), high-density lipoprotein cholesterol (HDL-c) ≤ 1.5 mmol/l (adjusted OR = 1.70, 95% CI = 1.16–2.49) and low-density lipoprotein cholesterol (LDL-c) > 3.12 mmol/l (adjusted OR = 1.47, 95% CI = 1.08–2.00) subjects, under the recessive genetic model. We also found that rs2134095 interacted with age (Pinteraction=0.039), pre-BMI (Pinteraction=0.040) and TG (Pinteraction=0.025) influencing individual’s genetic susceptibility to GDM. The rs2134095 T>C is significantly associated with the risk of GDM by effect of a single locus and/or complex joint gene–gene and gene–environment interactions. Larger sample-size and different population studies are required to confirm the findings.