A Pro-metastatic tRNA Pathway.
A Pro-metastatic tRNA Pathway.
复制标题
促转移 tRNA 途径。
DOI：
10.1016/j.cell.2016.05.066
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发表时间：
2016
期刊：
影响因子：
64.5
通讯作者：
Dutta,Anindya
中科院分区：
文献类型：
--
作者：
Kuscu,Canan;Dutta,Anindya
tRNA是最为人所知的蛋白质合成全局调节的基本模块。Goodarzi等人现在表明，在转移性乳腺癌细胞中上调的两种tRNA增强了富含这些密码子的转录物的稳定性和翻译，导致促转移蛋白质产生的特异性增加。
tRNAs are best known as basic modules for global regulation of protein synthesis. Goodarzi et al. now show that two tRNAs upregulated in metastatic breast cancer cells enhance stability and translation of transcripts enriched with these codons, leading to specific increase in production of pro-metastatic proteins.