COUGHING FREQUENCY IN PATIENTS WITH PERSISTENT COUGH - ASSESSMENT USING A 24-HOUR AMBULATORY RECORDER
COUGHING FREQUENCY IN PATIENTS WITH PERSISTENT COUGH - ASSESSMENT USING A 24-HOUR AMBULATORY RECORDER
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DOI：
10.1183/09031936.94.07071246
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发表时间：
1994-07-01
影响因子：
24.3
通讯作者：
CHUNG, KF
中科院分区：
文献类型：
--
作者：
HSU, JY;STONE, RA;CHUNG, KF
咳嗽是许多呼吸系统疾病的重要症状。我们测定了正常受试者、哮喘患者或原因不明的持续咳嗽患者咳嗽的频率和日变化。我们使用便携式固态多通道录音机记录24小时内的咳嗽声音。音频信号由绑在胸壁上的单向麦克风记录下来，来自下呼吸肌的肌电图（EMG）信号同时与表面电极记录。在ibm兼容的计算机上检查记录的数字数据，并计算由咳嗽引起的典型信号（通过自愿或实验诱导的咳嗽来评估）。在12名正常受试者中，仅记录了24小时内0-16次咳嗽。在21名有慢性咳嗽史（“哮喘”）的稳定哮喘患者中，中位数为282次（范围：45-1,577次），在14名以每日干咳为主要症状（“慢性咳嗽”）的患者中，中位数为794次（64-3,639次）。在两组患者中，咳嗽的次数每天都有变化，这样最少的次数发生在凌晨2点到5点之间。（
Cough is an important symptom of many respiratory disorders. We determined the frequency and diurnal variation of cough in normal subjects and in patients with asthma or with persistent cough of unknown cause.We used a portable, solid-state, multiple-channel recorder to record cough sounds over a 24 h period. The audio-signal was recorded from a unidirectional microphone strapped over the chest wall, and electromyographic (EMG) signals from the lower respiratory muscles were simultaneously registered with surface electrodes. The recorded digital data were examined on an IBM-compatible computer and the typical signals induced by cough (as assessed by voluntary or experimentally-induced cough) were counted.In 12 normal subjects, only 0-16 coughs were recorded over 24 h. In 21 stable asthmatics with a history of chronic cough (''asthma'') the medium number was 282 (ranges: 45-1,577), and in 14 patients with the predominant symptom of daily dry coughs (''chronic coughers'') the median number was 794 (64-3,639). In both groups of patients, there was a diurnal variation of coughs, such that the least numbers occurred between 2 and 5 am. (