D-Amphetamine enhances skilled reaching after ischemic cortical lesions in rats
D-Amphetamine enhances skilled reaching after ischemic cortical lesions in rats
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DOI：
10.1016/j.neulet.2005.01.036
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发表时间：
2005-06-03
影响因子：
2.5
通讯作者：
Jones, TA
中科院分区：
文献类型：
--
作者：
Adkins, DL;Jones, TA
大鼠单侧感觉运动皮层（SMC）损伤损害对侧前肢的伸手和抓握运动。这些损伤可以通过对熟练的伸展任务进行运动康复训练来改善，但训练可能远远不足以使动物恢复到损伤前的表现水平。由于D-安非他明（AMPH）已被发现可以促进神经可塑性反应的伤害，并结合一些（但不是所有）类型的康复训练是非常有益的，我们在这个实验中问它是否可以提高康复训练的效果，熟练的达到。在SMC单侧缺血（内皮素-1诱导）损伤后10至14天，给予成年大鼠3周的AMPH（1 mg/kg）方案，并每日进行熟练的伸手任务（单个颗粒回收任务）的康复训练。与盐水注射对照组相比，AMPH治疗不仅显着改善了达到性能，AMPH治疗组大鼠在康复训练期结束时超过了损伤前的性能水平。在AMPH中的更大的性能相比，盐水治疗的大鼠在1个月时仍然是明显的，但不是在2个月和3个月后，康复训练结束。因此，AMPH治疗可以大大提高单侧SMC病变后熟练达到任务的康复训练的疗效，但可能需要交替注射和训练方案，以产生永久性的改善。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Unilateral sensorimotor cortical (SMC) lesions in rats impair reaching and grasping movements of the contralateral forelimb. These impairments can be improved using motor rehabilitative training on a skilled reaching task, but the training may be far from sufficient to return animals to pre-lesion levels of performance. Because D-amphetamine (AMPH) has been found to promote neuroplastic responses to injury and to be very beneficial when combined with some (but not all) types of rehabilitative training, we asked in this experiment whether it could improve the efficacy of rehabilitative training in skilled reaching. Ten to 14 days after unilateral ischemic (endothelin-1 induced) lesions of the SMC, adult rats were given a 3-week regimen of AMPH (1 mg/kg) coupled with daily rehabilitative training on a skilled reaching task, the single pellet retrieval task. AMPH treatment not only dramatically improved reaching performance compared with saline-injected controls, the AMPH treated rats surpassed pre-lesion levels of performance by the end of the rehabilitative training period. The greater performance in AMPH compared to saline-treated rats was still evident at 1 month, but not at 2 and 3 months, after the end of rehabilitative training. Thus, AMPH treatment can greatly enhance the efficacy of rehabilitative training on a skilled reaching task after unilateral SMC lesions, but alternate injection and training regimes may be needed to produce permanent improvements. (c) 2005 Elsevier Ireland Ltd. All rights reserved.