PERFORANT PATHWAY CHANGES AND THE MEMORY IMPAIRMENT OF ALZHEIMERS-DISEASE
PERFORANT PATHWAY CHANGES AND THE MEMORY IMPAIRMENT OF ALZHEIMERS-DISEASE
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DOI：
10.1002/ana.410200406
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发表时间：
1986-10-01
影响因子：
11.2
通讯作者：
DAMASIO, AR
中科院分区：
文献类型：
--
作者：
HYMAN, BT;VANHOESEN, GW;DAMASIO, AR
穿通通路是一个大的神经元投射，产生于海马旁回内嗅皮层的第二层和第三层。它是海马结构输入的主要来源。在 11 个阿尔茨海默病病例中，我们发现穿通通路的起源细胞中出现神经原纤维缠结。此外，穿通通路的终止区（位于齿状回分子层的外部三分之二）包含明显的神经炎斑层。 8 名对照受试者均未出现此类变化。这些深刻的改变有效地断开了海马结构与关联皮质和边缘皮质的连接。由于海马和海马旁回在学习中的核心作用，穿通通路的病理变化可能通过妨碍海马的正常运作来解释阿尔茨海默氏病记忆障碍的某些方面。
The perforant pathway is a large neuronal projection that arises from layers II and III of the entorhinal cortex of the parahippocampal gyrus. It is the principal source of input to the hippocampal formation. In 11 cases of Alzheimer''s disease, we have found that neurofibrillary tangles develop in the cells of origin of the perforant pathway. In addition, the termination zone of the perforant pathway, in outer two thirds of the molecular layer of the dentate gyrus, contains a distinct layer of neuritic plaques. None of the 8 control subjects had such changes. These profound alterations effectively disconnect the hippocampal formation from the association and limbic cortices. Because of the central role of the hippocampus and parahippocampal gyrus in learning, it is likely that pathological changes in the perforant pathway, by precluding normal hippocampal operation, account for some aspects of the memory impairment in Alzheimer''s disease.