The evolutionary history of lymphoid organs
The evolutionary history of lymphoid organs
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DOI：
10.1038/ni1435
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发表时间：
2007-02-01
影响因子：
30.5
通讯作者：
Bleul, Conrad C.
中科院分区：
文献类型：
--
作者：
Boehm, Thomas;Bleul, Conrad C.
淋巴器官是淋巴细胞发育和免疫反应的重要调节者。在脊椎动物进化过程中，初级淋巴器官的出现早于次级淋巴器官。在进化和个体发育过程中的初级淋巴细胞生成位点中，B细胞分化的位点有很大差异，尽管它们通常具有骨髓淋巴特征。相比之下，T 细胞仅在一个位点发生分化，即胸腺。基于这些观察结果和可变多样性连接基因重组的已知特征，我们提出了脊椎动物进化过程中不同淋巴细胞谱系的连续规范的模型。根据我们的模型，T 细胞是第一个获得可变多样性连接型受体的淋巴细胞，而胸腺是脊椎动物中第一个进化来处理潜在自身反应性、体细胞多样化 T 细胞受体的淋巴器官。
Lymphoid organs are important regulators of lymphocyte development and immune responses. During vertebrate evolution, primary lymphoid organs appeared earlier than secondary lymphoid organs. Among the sites of primary lymphopoiesis during evolution and ontogeny, those for B cell differentiation have differed considerably, although they often have had myelolymphatic characteristics. In contrast, only a single site for T cell differentiation has occurred, exclusively the thymus. Based on those observations and the known features of variable-diversity-joining gene recombination, we propose a model for the successive specification of different lymphocyte lineages during vertebrate evolution. According to our model, T cells were the first lymphocytes to acquire variable-diversity-joining - type receptors, and the thymus was the first lymphoid organ to evolve in vertebrates to deal with potentially autoreactive, somatically diversified T cell receptors.