RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.
RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.
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RMP 预测肝细胞癌的生存率和辅助 TACE 反应
DOI：
10.18632/oncotarget.3092
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发表时间：
2015-02-20
期刊：
影响因子：
--
通讯作者：
Wang HY
中科院分区：
文献类型：
--
作者：
Zhang J;Jiang TY;Jiang BG;Yang C;Tan YX;Yang N;Pan YF;Ding ZW;Yang GZ;Wu MC;Dong LW;Wang HY
辅助经导管动脉化疗栓塞（TACE）可以预防肝细胞癌（HCC），并与减少疾病复发和改善手术后预后相关。然而，TACE术后肝功能恶化会对患者预后产生负面影响，并限制了其作为延长生存期的选择。我们分析了两个独立的队列，共包括510例接受肿瘤切除术的HCC患者。采用免疫组化法检测rpb5介导蛋白（RMP）的表达，并评估其与复发率和辅助TACE治疗反应的关系。在HCC患者中，肿瘤中RMP的表达与年龄、性别、肿瘤大小、门静脉浸润、TNM分期、BCLC分期及总生存期有关。在RMP高表达的患者中，术后辅助TACE与早期复发相关。即使在肿瘤较小（不大于5cm）或没有静脉侵犯的患者中，RMP状态也与辅助TACE的反应相关。肿瘤中的RMP状态可能是估计HCC患者预后的有用指标，并有助于选择可能受益于辅助TACE以预防复发的患者。
Adjuvant transcatheter arterial chemoembolization (TACE) protects against hepatocellular carcinoma (HCC) and is associated with reduced disease recurrence and improved outcome after surgery. However, deterioration of liver function after TACE negatively impacts the patient prognosis and limits it use as an option to prolong survival. We analyzed two independent cohorts that included a total of 510 patients with HCC who had undergone tumor resection. Immunohistochemistry assay was used to measure RPB5-mediating protein (RMP) expression and assessed their association with recurrence rate and response to therapy with adjuvant TACE. In patients with HCC, the expression of RMP in tumor is associated with age, gender, tumor size, portal venous invasion, TNM stages, BCLC stages and overall survival. Among patients with high RMP expression, adjuvant TACE after resection was associated with early recurrence. Even in the patients with small tumor size (no more than 5 cm) or no venous invasion, RMP status is associated with response to adjuvant TACE. RMP status in tumors may be a useful marker in estimating prognosis in patients with HCC and in assisting in the selection of patients who are likely to benefit from adjuvant TACE to prevent relapse.
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