Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria
Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria
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DOI：
10.1042/bst0310785
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发表时间：
2003-08-01
影响因子：
3.9
通讯作者：
Weiss, J
中科院分区：
文献类型：
--
作者：
Weiss, J
脂多糖结合蛋白（LBP）和杀菌/通透性增加蛋白（BPI）是密切相关的内毒素结合蛋白，它们以协调的方式起作用，促进宿主对入侵的革兰氏阴性细菌的综合反应。BPI和LBP在结构和功能上的差异，以及它们在动员上的差异，允许在细菌入侵开始时对少量细菌产生高度敏感的促炎反应，然后有效地消除活菌及其残余物和内毒素驱动的炎症。
Lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are closely related endotoxin-binding proteins that function in a co-ordinated manner to facilitate an integrated host response to invading Gram-negative bacteria. Differences in the structure and function of BPI and LBP, as well as differences in their mobilization, permit highly sensitive pro-inflammatory responses to small numbers of bacteria at the onset of bacterial invasion and, later, efficient elimination of viable bacteria and their remnants and of endotoxin-driven inflammation.