2-Deoxy-2-iodo-β-glucopyranosyl fluorides:: Mild and highly stereoselective glycosyl donors for the synthesis of 2-deoxy-β-glycosides from β-hydroxy ketones
2-Deoxy-2-iodo-β-glucopyranosyl fluorides:: Mild and highly stereoselective glycosyl donors for the synthesis of 2-deoxy-β-glycosides from β-hydroxy ketones
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DOI：
10.1021/ol027257h
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发表时间：
2003-01-09
期刊：
影响因子：
5.2
通讯作者：
Roush, WR
中科院分区：
文献类型：
--
作者：
Blanchard, N;Roush, WR
2-脱氧-2-碘-β-吡喃葡萄糖氟化物14是一种高度立体选择性的吡喃葡萄糖基供体，可在温和的条件下被激活。将这种新的糖基供体应用于包括β-羟基酮在内的多种受体的糖苷化反应，得到了高效和立体选择性的β-糖苷。
2-Deoxy-2-iodo-beta-glucopyranosyl fluoride 14 is a highly stereoselective glucopyranosyl donor that may be activated under mild conditions. Application of this new glycosyl donor to the glycosidation reactions of a variety of acceptors including beta-hydroxy ketones affords beta-glycosides with high efficiency and stereoselectivity.