Circadian phase-shifted rats show normal acquisition but impaired long-term retention of place information in the water task
Circadian phase-shifted rats show normal acquisition but impaired long-term retention of place information in the water task
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DOI：
10.1006/nlme.1999.3957
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发表时间：
2001-01-01
影响因子：
2.7
通讯作者：
McDonald, RJ
中科院分区：
文献类型：
--
作者：
Devan, BD;Goad, EH;McDonald, RJ
人们认为昼夜节律可能会影响学习和记忆过程。然而，支持这一观点的研究并没有将记忆障碍与其他表现缺陷分开。此外，已发表的报告没有指定受昼夜节律系统影响的记忆系统的类型。本研究评估了相移对水迷宫中位置导航的获取和表达的影响，这是一项对海马功能障碍敏感的任务。结果表明，大鼠的相移昼夜节律损害了位置信息的表达在保留测试，但不初始收购或编码的位置信息。这些结果表明，昼夜节律的破坏可能会损害巩固以前编码的海马位置信息。(C)北京：科学出版社.
It is thought that circadian rhythms may influence learning and memory processes. However, research supporting this view does not dissociate a mnemonic impairment from other performance deficits. Furthermore, published reports do not specify the type of memory system influenced by the circadian system. The present study assessed the effects of phase shifting on acquisition and expression of place navigation in the water maze, a task sensitive to hippocampal dysfunction. The results showed that phase-shifting circadian rhythms in rats impaired the expression of place information on a retention test but not initial acquisition or encoding of place information. These results suggest that disruption of circadian rhythms may impair consolidation of previously encoded hippocampal place information. (C) 2001 Academic Press.