Brucella: a Mr "Hide" converted into Dr Jekyll
Brucella: a Mr "Hide" converted into Dr Jekyll
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DOI：
10.1016/j.micinf.2008.07.007
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发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
Gorvel, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Gorvel, Jean-Pierre
大卫布鲁斯博士（1855-1931）首先将布鲁氏菌病的病原体鉴定为一种小的格兰氏阴性α-变形杆菌，后来迈耶和肖以他的荣誉将其称为羊种布鲁氏菌。现在。四种菌株在患有B的人类中表现出致病性。melitensis是宿主特异性最低的，也是对人类最具感染性的。其他菌株是猪种布鲁氏菌和牛种布鲁氏菌，最近报告了人类感染鲸目布鲁氏菌的病例。为什么这种重新出现的疾病如此难以对抗，证据表明，致病细菌已经发展出躲避免疫识别的策略。(C)2008年，Elsevier Masson SAS。All rights reserved.
Dr David Bruce (1855-1931) first identified the causative agent of brucellosis as a small Gran-negative alpha-Proteobacterium, which was later on called Brucella melitensis in his honor by Meyer and Shaw. Nowadays. four strains exhibit pathogenicity in humans with B. melitensis being the least host specific and also the most infectious for humans. The other strains are Brucella suis and Brucella abortus and more recently human cases being infected with Brucella cetaceae have been reported. Why Such a reemerging disease is so difficult to fight, evidence shows that the pathogenic bacterium has developed strategies to hide from immune recognition. (C) 2008 Elsevier Masson SAS. All rights reserved.