Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14
Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14
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DOI：
10.1111/j.1440-1843.2007.01227.x
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发表时间：
2008-03
期刊：
影响因子：
6.9
通讯作者：
D. Inoue;H. Kubo;Takahiko Sasaki;H. Yasuda;M. Numasaki;Hidetada Sasaki;M. Yamaya
中科院分区：
文献类型：
--
作者：
D. Inoue;H. Kubo;Takahiko Sasaki;H. Yasuda;M. Numasaki;Hidetada Sasaki;M. Yamaya
背景与目的：普通感冒是哮喘加重和慢性阻塞性肺疾病的主要原因。据报道，超过50%的普通感冒病例是由鼻病毒引起的。在之前的研究中，我们报道了鼻病毒感染培养的气道细胞通过激活p44/42丝裂原活化蛋白激酶（p44/42 MAPK）途径诱导MUC5AC粘蛋白过量产生和高分泌。本研究的目的是研究红霉素对RV14诱导的气道粘蛋白过量产生和分泌的影响。
Background and objective: The common cold is a major cause of asthma exacerbation and chronic obstructive lung disease. Rhinovirus is reported to be responsible for more than 50% of cases of the common cold. In a previous study, we reported that rhinovirus infection of cultured airway cells induced MUC5AC mucin overproduction and hypersecretion by activating the p44/42 mitogen‐activated protein kinase (p44/42 MAPK) pathway. The aim of this study was to examine the effect of erythromycin on RV14‐induced airway mucin overproduction and hypersecretion.