Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat dentate gyrus in vivo
Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat dentate gyrus in vivo
复制标题
槲皮素可缓解体内慢性铅暴露引起的大鼠齿状回突触可塑性损伤
DOI：
10.1007/s00210-008-0301-z
复制
发表时间：
2008-07-01
影响因子：
3.6
通讯作者：
Ruan, Di-Yun
中科院分区：
文献类型：
--
作者：
Hu, Pu;Wang, Ming;Ruan, Di-Yun
越来越多的证据表明，铅（Pb）产生损害部分通过氧化应激。虽然许多研究人员已经研究了一些抗氧化营养素对铅毒性的保护作用，但关于抗氧化剂对铅诱导的突触可塑性损伤的影响的信息很少。槲皮素是一种强抗氧化剂和自由基清除剂，是天然黄酮类化合物的代表性分子，在果蔬中含量丰富。先前的研究发现，槲皮素在许多情况下具有神经保护作用。本研究旨在探讨槲皮素对慢性铅暴露所致成年大鼠海马齿状回（DG）突触可塑性损伤的影响。结果表明，槲皮素能显著增强铅暴露组大鼠DG区的I/O、PPR和长时程增强（LTP）。此外，槲皮素治疗后，海马铅浓度部分降低。这些结果表明，槲皮素治疗可以减轻慢性铅中毒引起的突触可塑性损害，可能是一种潜在的治疗干预，以治疗铅诱导的认知功能障碍。
Increasing evidence suggests that lead (Pb) produces impairments partly through oxidative stress. Though many researchers have investigated protective effect of some antioxidant nutrients against Pb toxicity, little information is available about the effect of antioxidants on Pb-induced impairment of synaptic plasticity. Quercetin, a strong antioxidant and radical scavenger, is the representative natural flavonoid molecule abundant in fruits and vegetables. Previous studies have found that quercetin was neuroprotective in many cases. This study was designed to evaluate the effect of quercetin on chronic Pb exposure-induced impairment of synaptic plasticity in adult rat dentate gyrus (DG) area in vivo. The input/output (I/O) functions, paired-pulse reactions (PPR), excitatory postsynaptic potential (EPSP), and population spike (PS) amplitude were measured in the DG area of different groups of rats in response to stimulation applied to the lateral perforant path. The results showed that the depressedI/O, PPR, and long-term potentiation (LTP) of Pb-exposed group were significantly increased by quercetin treatment. In addition, hippocampal Pb concentration was partially reduced after quercetin treatment. These findings suggest that quercetin treatment could relieve chronic Pb exposure-induced impairment of synaptic plasticity and might be a potential therapeutic intervention to cure cognitive deficits induced by Pb.