Effectiveness of two-step (consecutive) embryo transfer in patients who have two embryos on day 2: comparison with cleavage-stage embryo transfer
Effectiveness of two-step (consecutive) embryo transfer in patients who have two embryos on day 2: comparison with cleavage-stage embryo transfer
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DOI：
10.1016/j.fertnstert.2004.07.974
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发表时间：
2005-03-01
影响因子：
6.7
通讯作者：
Noda, Y
中科院分区：
文献类型：
--
作者：
Goto, S;Shiotani, M;Noda, Y
目的：为了评估在第2天只有两个胚胎的患者，（连续）胚胎移植（ET）程序，其中在第2天移植卵裂胚胎，在第5天移植单个囊胚。设计：观察性比较研究。设置：私人IVF诊所。患者：在第2天有两个胚胎的患者中进行了90个两步ET周期（两步组）。在年龄和不孕症匹配的患者中进行了90个为期2天的ET周期，这些患者在第2天有两个胚胎（对照组）。干预措施：切割ET，一个胚胎的延长培养，和第二次囊胚移植。主要结果测量：着床率和妊娠率。结果：两步法组的妊娠率和种植率分别为33.3%和17.2%，显著高于对照组的18.9%和9.4%。两步移植组中有39例（43.3%）因未获得有活力的囊胚而不能进行第二步移植，但其中4例妊娠。结论：两步移植结合第2天胚胎移植和囊胚移植，是胚胎数量不足的患者进行胚胎移植的有效选择。(c)2005年，美国生殖医学会。
Objective: To evaluate the effectiveness, for patients who have only two embryos on day 2, of a two-step (consecutive) embryo transfer (ET) procedure in which a cleaved embryo is transferred on day 2 and a single blastocyst is transferred on day 5.Design: Observational comparative study.Setting: Private IVF clinic.Patient(s): Ninety two-step ET cycles were performed in patients who had two embryos on day 2 (two-step group). Ninety day-2 ET cycles were performed in age- and infertility-matched patients who had two embryos on day 2 (control group).Intervention(s): Cleaved-ET, extended culture of one embryo, and a second transfer of a blastocyst.Main Outcome Measure(s): Implantation and pregnancy rates.Result(S): The pregnancy and implantation rates in the two-step group (respectively 33.3% and 17.2%) were significantly higher than those in the control group (18.9% and 9.4%). Thirty-nine of the patients in the two-step Group (43.3%) could not proceed to the second step of ET because no viable'blastocyst could be obtained, but four of them conceived anyway.Conclusion(s): Taking advantage of both day-2 ET and blastocyst transfer, two-step ET may be an effective option for ET in patients who have an insufficient number of embryos. (c) 2005 by American Society for Reproductive Medicine.