Single-voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus.
Single-voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus.
复制标题
4.0 T 下的单体素 1H PRESS：前扣带回和海马测量的精度和变异性。
DOI：
10.1002/nbm.1055
复制
发表时间：
2006
影响因子：
2.9
通讯作者：
Steen,RGrant
中科院分区：
文献类型：
--
作者：
Venkatraman,TalaignairN;Hamer,RobertM;Perkins,DianaO;Song,AllenW;Lieberman,JeffreyA;Steen,RGrant
The precision [coefficient of variation or CV (%) = 100SD/X] of single‐voxel point resolved spectroscopic data was characterized bilaterally, in anterior cingulate and in hippocampus, at 4.0 T in a healthy subject. Data acquisition was replicated 10 times after voxel repositioning and readjusting higher order shims. Precision measurements show that the scan‐to‐scan precision is better in anterior cingulate than in hippocampus, with an average CV of 9.2% (for total NAA, tCho and Cr) in anterior cingulate and 13.9% in hippocampus. Variability measurements made by the same method in 24 healthy subjects and in 29 schizophrenia patients showed that there is substantial biological variability in metabolite levels, even in healthy subjects. Simple calculations suggest that more than 200 subjects would be needed to detect a 5% difference in NAA between patients and controls. Copyright © 2006 John Wiley & Sons, Ltd.
