Long-Term Survivors of Childhood Cancers in the United States
Long-Term Survivors of Childhood Cancers in the United States
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DOI：
10.1158/1055-9965.epi-08-0988
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发表时间：
2009-04-01
影响因子：
3.8
通讯作者：
Feuer, Eric J.
中科院分区：
文献类型：
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作者：
Mariotto, Angela B.;Rowland, Julia H.;Feuer, Eric J.
目的：估计截至2005年，美国儿童时期（0-19岁）被诊断患有癌症的人数，重点是存活>30年的人。方法：为了估计儿童癌症幸存者的全国患病率，我们使用了1975年至2004年的监测流行病学和最终结果项目的数据。使用外推至1975年以前的发病率和生存率模型估计1975年以前诊断的长期儿童癌症幸存者。结果：我们估计截至2005年1月1日，美国共有328，652名儿童癌症幸存者，其中24%的儿童癌症幸存者自诊断以来已存活超过30年。存活人数最多的癌症部位是脑（51，650），急性淋巴细胞白血病（49，271），生殖细胞肿瘤（34，169）和霍奇金淋巴瘤（31，598）。>30年前诊断的存活者比例较高的部位是生殖细胞（43%），软组织（38%），肾脏（34%）和骨骼（26%）。从康涅狄格州的数据的历史趋势表明，所有的儿童癌症situ.Conclusion生存的重大改善：儿童癌症的幸存者的数量预计将增加，在未来的救生治疗进展后，1970年推出，特别是急性淋巴细胞白血病。由于这一人群与疾病相关的发病率和死亡率的风险增加，因此了解儿童时期接受治疗的幸存者人数对于确定国家癌症负担和规划这些人未来的医疗保健需求都很重要。（Cancer Epidemiol Biornarkers Prev 2009;18（4）：1033-40）
Purpose: To estimate the number of individuals in the United States diagnosed with cancer as children (ages 0-19 years) as of 2005, with a focus on those surviving for >30 years.Methods: To estimate the national prevalence of survivors of childhood cancers, we used data from the Surveillance Epidemiology and End Results program from 1975 to 2004. Long-term childhood cancer survivors, diagnosed before 1975, were estimated using incidence and survival models extrapolated into years before 1975.Results: We estimated that there are a total of 328,652 survivors of childhood cancer in the United States as of January 1, 2005, of these, 24% have survived >30 years since diagnosis. The cancer sites with the largest number of survivors are brain (51,650), acute lymphoblastic leukemia (49,271), germ cell tumors (34,169), and Hodgkin lymphoma (31,598). Sites with higher proportions of survivors diagnosed >30 years ago are germ cell (43%), soft tissue (38%), renal (34%), and bone (26%). Historical trends from Connecticut data show major improvements in survival for all of the childhood cancer sites.Conclusion: The number of survivors of childhood cancers is expected to increase in the future consequent to the lifesaving advances in treatment introduced after 1970, especially for acute lymphoblastic leukemia. Because this population is at increased risk for illness-related morbidity and mortality, appreciating the number of survivors who were treated as children is important both to determining the national cancer burden and planning for the future health care needs of these individuals. (Cancer Epidemiol Biornarkers Prev 2009;18(4):1033-40)