Effects of elevated lead and cadmium burdens on renal function and calcium metabolism.
Effects of elevated lead and cadmium burdens on renal function and calcium metabolism.
复制标题
铅和镉负荷升高对肾功能和钙代谢的影响。
DOI：
10.1080/00039896.1986.9937412
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Landrigan,PJ
中科院分区：
文献类型：
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作者：
Greenberg,A;Parkinson,DK;Fetterolf,DE;Puschett,JB;Ellis,KJ;Wielopolski,L;Vaswani,AN;Cohn,SH;Landrigan,PJ
为探讨铅、镉负荷增加的病理生理学意义，对38名铅、镉接触11 ~ 37年的工业工人进行了详细的肾功能检查和钙、磷、维生素D代谢评价。通过X射线荧光测量胫骨铅含量评估，58%的男性体内铅负荷升高，通过Ca-EDTA输注后铅排泄评估，36%的男性体内铅负荷升高。通过中子活化分析评估，肝脏或肾脏镉负荷升高31%。所有工人的credibleclearance均正常。1名工人出现高尿酸血症，2名工人出现蛋白尿; 3名工人β 1微球蛋白排泄增加，1名工人尿酸化能力下降。最大尿浓缩能力在一个重要部分中异常，即，52%的男人。个体与高铅负荷有轻微的平均血清磷下降，但没有伴随磷酸盐尿。血钙未见异常。22%的受试者有高钙尿症，两人有低维生素D水平，但这些异常与重金属负荷无关。在这一仔细描述的慢性铅和钙暴露男性组中，明确的（如果是亚临床的）对肾功能和血清磷的影响是明显的，但对钙或维生素D代谢没有影响。
To assess the pathophysiologic significance of increased body burdens of lead and cadmium, detailed renal function studies and evaluation of calcium, phosphorus, and vitamin D metabolism were carried out in 38 industrial workers exposed to lead and cadmium for 11 to 37 yr. Body burden of lead, as assessed by x-ray fluorescence measurement of tibia lead content, was elevated in 58% of the men and, when assessed by excretion of lead after Ca-EDTA infusion, was elevated in 36%. Liver or kidney cadmium burden, as assessed by neutron activation analysis, was elevated in 31%. Creatinine clearance was normal in all workers. One worker was hyperuricemic and two were proteinuric; three had increased β1microglobulin excretion and one had diminished urinary acidifying ability. Maximal urinary concentrating ability was abnormal in a significant fraction, i.e., 52% of the men. Individuals with a high lead burden had a slight decrease in mean serum phosphorus but no accompanying phosphaturia. There was no abnormality of serum calcium. Twenty-two percent of subjects were hypercalciuric and two had low vitamin D levels, but these abnormalities bore no relation to heavy metal burden. In this carefully characterized group of men with chronic lead and calcium exposure, definite, if subclinical, effects on renal function and serum phosphorus but not calcium or vitamin D metabolism were demonstrable.