A STUDY OF THE SECRETORY IMMUNE SYSTEM OF THE FEMALE GENITAL TRACT
A STUDY OF THE SECRETORY IMMUNE SYSTEM OF THE FEMALE GENITAL TRACT
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女性生殖道分泌免疫系统的研究
DOI：
10.1111/j.1471-0528.1975.tb00578.x
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
H. Fox
中科院分区：
文献类型：
--
作者：
R. Rebello;F. Green;H. Fox
女性生殖道中的免疫细胞主要存在于子宫颈内膜中。该部位产生的主要免疫球蛋白是 IgA，这与宫颈内膜上皮中分泌成分的存在一起表明宫颈内膜中存在与胃肠道和呼吸道中发现的类似的局部分泌性免疫系统。这种局部分泌性免疫系统似乎是宫颈粘液中免疫球蛋白的主要来源，宫颈阴道分泌物中分泌性 IgA 的存在提供了针对病毒和细菌感染的有效保护机制。分泌型 IgA 还非特异性地对抗外源抗原，并且可能通过结合精子抗原，在免疫介导的不育症中发挥作用。
Immunocytes in the female genital tract are found principally in the endocervix. The predominant immunoglobulin produced in this site is IgA and this, together with the presence of secretory component in endocervical epithelium, indicates that a local secretory immune system, similar to that found in the gastrointestinal and respiratory tracts, exists in the endocervix. This local secretory immune system appears to be the major source of immunoglobulins in cervical mucus and the presence of secretory IgA in cervico‐vaginal secretions provides an effective protective mechanism against viral and bacterial infections. Secretory IgA also acts non‐specifically against exogenous antigens and may, by binding sperma‐tozoal antigens, play a role in immunologically mediated infertility.