Subcutaneous implantable venous access device erosion through the skin in patients treated with anti-vascular endothelial growth factor therapy: a case series.
Subcutaneous implantable venous access device erosion through the skin in patients treated with anti-vascular endothelial growth factor therapy: a case series.
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接受抗血管内皮生长因子治疗的患者皮下植入式静脉接入装置经皮肤侵蚀：病例系列。
DOI：
10.1097/cad.0b013e3282f2c063
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发表时间：
2008
影响因子：
2.3
通讯作者：
H. Moore
中科院分区：
文献类型：
--
作者：
K. Almhanna;R. Pelley;G. Thomas Budd;Jon Davidson;H. Moore
皮下植入式静脉输液器（IVAD）通常用于肿瘤学实践。它们有助于化疗、液体和血液制品的管理。IVAD相关并发症的发生率并不罕见，包括感染、血栓形成和出血。据报道，IVAD通过皮肤侵蚀继发于感染或缺乏经验的处理。我们报告三例IVAD侵蚀通过皮肤的患者接受抗血管内皮生长因子治疗。抗血管内皮生长因子药物越来越多地用于实体瘤的治疗。这类药物与伤口愈合延迟和血栓栓塞有关。据我们所知，这是第一个病例系列IVAD侵蚀通过皮肤，在接受这种治疗的患者。
Subcutaneous implantable venous access devices (IVADs) are commonly used in oncology practice. They facilitate the administration of chemotherapy, fluids and blood products. The incidence of IVAD-related complications is not uncommon, and includes infection, thrombosis and bleeding. IVAD erosion through the skin has been reported secondary to infection or inexperienced handling. We report three cases of IVAD erosion through the skin in patients treated with anti-vascular endothelial growth factor therapy. Anti-vascular endothelial growth factor agents are increasingly used in the treatment of solid tumors. This class of drugs has been associated with delayed wound healing and thromboembolism. To our knowledge, this is the first case series of IVAD erosion through skin, in patients receiving such therapy.