Monoclonality of composite large-cell neuroendocrine carcinoma and invasive intestinal-type mucinous adenocarcinoma of the cervix : a case study
Monoclonality of composite large-cell neuroendocrine carcinoma and invasive intestinal-type mucinous adenocarcinoma of the cervix : a case study
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复合性大细胞神经内分泌癌和宫颈浸润性肠型粘液性腺癌的单克隆性：病例研究
DOI：
10.1097/pgp.0b013e318261c35b
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发表时间：
2013
影响因子：
2.4
通讯作者：
Nakamura Y
中科院分区：
文献类型：
--
作者：
Yasuoka H;Tsujimoto M;Ueda M;Kodama R;Iwahashi Y;Inagaki M;Mabuchi Y;Ino K;Sanke T;Nakamura Y
据报道，一例罕见的宫颈混合癌，由大细胞神经内分泌癌和侵袭性肠型粘液腺癌组成。大细胞神经内分泌癌由中型至大型细胞的实性巢、片和小梁组成，嗜铬粒蛋白-A和CD56呈阳性。侵袭性肠型粘液腺癌显示出稀疏分散的嗜铬粒蛋白-A 免疫反应性。使用 X 染色体克隆性测定，这两种成分显示出单克隆性模式。这些结果表明大细胞神经内分泌癌可能起源于侵袭性粘液腺癌。
A rare case of mixed carcinoma of the cervix is reported, composed of a large-cell neuroendocrine carcinoma and an invasive intestinal-type mucinous adenocarcinoma. The large-cell neuroendocrine carcinoma was composed of solid nests, sheets, and trabeculae of medium-sized to large-sized cells, and was positive for chromogranin-A and CD56. The invasive intestinal-type mucinous adenocarcinoma showed sparsely scattered immunoreactivity for chromogranin-A. Using an X-chromosome clonality assay, these 2 components showed patterns of monoclonality. These results suggest that the large-cell neuroendocrine carcinoma may have arisen from the invasive mucinous adenocarcinoma.