Comparison of anaplastic large cell Ki-1 lymphomas and microvillous lymphomas in their immunologic and ultrastructural features.
Comparison of anaplastic large cell Ki-1 lymphomas and microvillous lymphomas in their immunologic and ultrastructural features.
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间变性大细胞 Ki-1 淋巴瘤和微绒毛淋巴瘤的免疫学和超微结构特征的比较。
DOI：
10.1097/00000478-199011000-00006
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Collins,RD
中科院分区：
文献类型：
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作者：
Kinney,MC;Glick,AD;Stein,H;Collins,RD
间变性大细胞Ki-1恶性淋巴瘤（ML）类似于微绒毛淋巴瘤，具有明显的窦状生长模式的多形性浸润。间变性大细胞Ki-1 MLs的超微结构特征及其与微绒毛MLs的免疫学关系尚未得到充分评价。我们对23例间变性大细胞Ki-1型淋巴细胞进行了免疫学和超微结构研究，并与7例微绒毛型淋巴细胞进行了比较。间变性大细胞Ki-1 MLs主要为T细胞型（13例），3例标记为B; 7例免疫表型不明确。6例微绒毛ML表达单型细胞质或表面免疫球蛋白，其余病例可能具有B细胞表型（LN-1+，UCHL 1-）。所有微绒毛ML均为Ki-1/Ber-H2（CD 30）阴性。上皮细胞膜抗原（EMA）标记大多数间变性大细胞Ki-1的ML，除了那些B细胞型，而所有微绒毛ML EMA阴性。
Anaplastic large cell Ki-1 malignant lymphomas (MLs) resemble microvillous lymphoma in having a pleomorphic infiltrate with a prominent sinus growth pattern. Ultra-structural features of anaplastic large cell Ki-1 MLs and their immunologic relationship to the microvillous MLs have not been thoroughly evaluated. We have studied 23 anaplastic large cell Ki-1 MLs immunologically as well as 14 cases ultrastructurally, and compared them with 7 cases of microvillous MLs. Anaplastic large cell Ki-1 MLs were predominantly T-cell in type (13 cases) with three cases marking as B; in seven cases the immunophenotype was not clearly defined. Six microvillous MLs expressed monotypic cytoplasmic or surface immunoglobin and the remaining case had a probable B-cell phenotype (LN-1+, UCHL1-). All microvillous MLs were Ki-1/Ber-H2 (CD30) negative. Epithelial membrane antigen (EMA) marked most ana-plastic large cell Ki-1 MLs, except those of B-cell type, whereas all microvillous MLs were EMA negative.