Risk of incident age-related eye diseases in people with an affected sibling - The Beaver Dam eye study
Risk of incident age-related eye diseases in people with an affected sibling - The Beaver Dam eye study
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DOI：
10.1093/aje/154.3.207
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发表时间：
2001-08-01
影响因子：
5
通讯作者：
Danforth, L
中科院分区：
文献类型：
--
作者：
Klein, BEK;Klein, R;Danforth, L
本研究的目的是确定大哥姐妹中与年龄相关的白内障和黄斑病变是否预示着弟弟姐妹中同样的发展。1988-1990年在威斯康辛州比弗达姆进行了一项基于人群的年龄相关眼病研究，并在5年后进行了随访检查。年龄相关性眼病的诊断是根据研究照片的评分进行的。来自488个兄弟姐妹中至少有两个兄弟姐妹的1088人可以为这些分析提供信息。作者计算了发生特定病变的比值比和95%置信区间，并在5年后确定是否有年长的兄弟姐妹在基线时患有该病变。核性白内障的优势比为1.65(95%可信区间CI: 0.91, 2.99)，皮质性白内障的优势比为1.62(95%可信区间CI: 0.92, 2.85)，后囊膜下白内障的优势比为1.95(95%可信区间CI: 0.48, 7.95)，软性白内障的优势比为1.82(95%可信区间CI: 0.91, 3.66)，视网膜色素上皮色素沉着的优势比为8.18(95%可信区间CI: 3.34, 20.08)，视网膜色素增加的优势比为3.59(95%可信区间CI: 1.71, 7.57)，渗出性年龄相关性黄斑病变的优势比为10.32（95%可信区间CI: 0.83, 128.58）。这些发现表明，与年龄相关的黄斑病变的病变可能有很强的家族决定因素，而与年龄相关的白内障则不那么重要，因为年龄较小的兄弟姐妹也有患相同病变的风险。
The purpose of this investigation was to determine whether age-related cataract and maculopathy in older siblings predicts development of the same in younger siblings. A population-based study of age-related eye diseases was conducted in 1988-1990 in Beaver Dam, Wisconsin, and a follow-up examination was performed 5 years later. Diagnoses of age-related eye diseases were assigned on the basis of gradings of study photographs. There were 1,088 people from 488 sibships with at least two siblings who could contribute information for these analyses. The authors computed odds ratios and 95% confidence intervals for developing the specific lesion and identifying it 5 years later if an older sibling had it at baseline. The odds ratios were 1.65 (95% confidence interval (CI): 0.91, 2.99) for nuclear cataract, 1.62 (95% Cl: 0.92, 2.85) for cortical cataract, 1.95 (95% CI: 0.48, 7.95) for posterior subcapsular cataract, 1.82 (95% CI: 0.91, 3.66) for soft drusen, 8.18 (95% CI: 3.34, 20.08) for retinal pigment epithelium depigmentation, 3.59 (95% CI: 1.71, 7.57) for increased retinal pigment, and 10.32 (95% CI: 0.83, 128.58) for exudative age-related maculopathy. These findings suggest that strong family determinants of lesions of age-related maculopathy are likely, less so for age-related cataract, which confer risk of the same lesion in a younger sibling.