Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder
Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder
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患有注意力缺陷/多动障碍的儿童和成人共享和独特的静息功能连接
DOI：
10.1038/s41398-020-0740-y
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发表时间：
2020-02-12
影响因子：
6.8
通讯作者：
Sun, Li
中科院分区：
文献类型：
--
作者：
Guo, Xiaojie;Yao, Dongren;Sun, Li
注意力缺陷多动障碍（ADHD）通常持续到成年期，伴随着症状的转变，包括ADHD成年期的多动/冲动减少和情感障碍的合并症增加。许多研究质疑ADHD从儿童到成年诊断的稳定性，ADHD儿童和ADHD成人之间共享和独特的异常功能连接（FC）尚未确定。我们的目的是探索ADHD儿童和ADHD成人的共同和不同的FC模式，并进一步研究了跨队列的预测使用确定的FC。在调查了儿童（34例ADHD儿童，28例HC）和成人（112例ADHD成人，77例HC）队列中来自健康对照（HC）的ADHD区分FC后，我们确定了队列之间共享和不同的异常FC模式及其与临床症状的相关性。此外，使用确定的FC的跨队列的可预测性进行了测试。ADHD-HC分类准确率儿童为84.4%，男性成人为81.0%。儿童和成人的ADHD辨别功能块位于默认模式网络（DMN）内网络和DMN与腹侧注意网络之间的网络中，与ADHD症状总分呈正相关。特别是，在ADHD儿童中，躯体运动网络和背侧注意网络之间的网络间FC是唯一受损的，与多动指数呈正相关;而DMN和边缘网络之间的异常网络间FC表现出更多的成人特异性ADHD功能障碍。他们的跨队列预测分别为70.4%和75.6%。这项工作为ADHD从儿童期到成年期的症状变化和病理生理连续性提供了影像学证据，表明FC可能作为ADHD诊断的潜在生物标志物。
Attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood, with a shift of symptoms including less hyperactivity/impulsivity and more co-morbidity of affective disorders in ADHDadult. Many studies have questioned the stability in diagnosing of ADHD from childhood to adulthood, and the shared and distinct aberrant functional connectivities (FCs) between ADHDchildand ADHDadultremain unidentified. We aim to explore shared and distinct FC patterns in ADHDchildand ADHDadult, and further investigated the cross-cohort predictability using the identified FCs. After investigating the ADHD-discriminative FCs from healthy controls (HCs) in both child (34 ADHDchild, 28 HCs) and adult (112 ADHDadult,77 HCs) cohorts, we identified both shared and distinct aberrant FC patterns between cohorts and their association with clinical symptoms. Moreover, the cross-cohort predictability using the identified FCs were tested. The ADHD-HC classification accuracies were 84.4% and 81.0% for children and male adults, respectively. The ADHD-discriminative FCs shared in children and adults lie in the intra-network within default mode network (DMN) and the inter-network between DMN and ventral attention network, positively correlated with total scores of ADHD symptoms. Particularly, inter-network FC between somatomotor network and dorsal attention network was uniquely impaired in ADHDchild, positively correlated with hyperactivity index; whereas the aberrant inter-network FC between DMN and limbic network exhibited more adult-specific ADHD dysfunction. And their cross-cohort predictions were 70.4% and 75.6% between each other. This work provided imaging evidence for symptomatic changes and pathophysiological continuity in ADHD from childhood to adulthood, suggesting that FCs may serve as potential biomarkers for ADHD diagnosis.