ASSOCIATIVE LEARNING IN APLYSIA - CELLULAR CORRELATES SUPPORTING A CONDITIONED FEAR HYPOTHESIS
ASSOCIATIVE LEARNING IN APLYSIA - CELLULAR CORRELATES SUPPORTING A CONDITIONED FEAR HYPOTHESIS
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DOI：
10.1126/science.7455692
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
KANDEL, ER
中科院分区：
文献类型：
--
作者：
CAREW, TJ;WALTERS, ET;KANDEL, ER
A.厌恶联想学习californica在动物的束缚和CNS的手术暴露中存活。这种学习表现在介导3种不同防御行为的经鉴定的运动神经元的细胞内记录的活动中：逃避运动、墨水和虹吸撤回。先前接受配对训练的动物在条件刺激存在的情况下，在测试刺激期间表现出对运动神经元的突触输入的显著促进。没有这种训练的动物没有表现出对运动神经元输入的促进作用。静息电位和输入电阻似乎不受条件反射的影响，并没有改变条件刺激的应用。防御反应的条件易化不能用条件刺激对运动神经元的阈下作用来解释。这一假说支持了失语症患者学会将条件刺激与恐惧样的中枢状态联系起来的假设。
Aversive associative learning in A. californica survives restraint of the animal and surgical exposure of the CNS. The learning is expressed in the intracellularly recorded activity of identified motor neurons mediating 3 different defensive behaviors: escape locomotion, inking and siphon withdrawal. Animals that had previously received paired training showed significant facilitation of synaptic input to motor neurons during test stimulation in the presence of the conditioned stimulus. Animals without such training showed no facilitation of input to the motor neurons. Resting potential and input resistance appeared unaffected by conditioning and were not altered by application of the conditioned stimulus. The conditioned facilitation of defensive responses cannot be explained by subthreshold actions of the conditioned stimulus on the motor neurons. The hypothesis that Aplysia learn to associate the conditioned stimulus with a fearlike central state is supported.